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Open Access Highly Accessed Research article

High prevalence of celiac disease among Saudi children with type 1 diabetes: a prospective cross-sectional study

Abdulrahman Al-Hussaini14*, Nimer Sulaiman2, Musa Al-Zahrani2, Ahmed Alenizi2 and Imad El Haj3

Author affiliations

1 Department of Pediatrics at Children's Hospital, King Fahad Medical City, Riyadh, Kingdom of Saudi Arabia

2 Children's Hospital, King Saud Medical City, Riyadh, Kingdom of Saudi Arabia

3 Department of Pathology, King Saud Medical City, Riyadh, Kingdom of Saudi Arabia

4 University of King Saud for Health Sciences, Division of Pediatric Gastroenterology, Hepatology & Nutrition, Children's Hospital, King Fahad Medical City, PO Box 59046, Riyadh, Postal code 11525, Kingdom of Saudi Arabia

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Citation and License

BMC Gastroenterology 2012, 12:180  doi:10.1186/1471-230X-12-180

Published: 23 December 2012

Abstract

Background

There is lack of data on prevalence of celiac disease (CD) in children with type 1 diabetes (T1D) in Arabs in the Middle East. The present investigation aims to study the prevalence rate and clinical characteristics of CD among Saudi children with T1D using a combination of the most sensitive and specific screening serologic tests (anti- tissue transglutaminase antibodies IgA [anti-TTG] and ednomyseal antibodies [EMA]) and to determine the lower cut-off value of anti- anti-TTG level that best predicts CD in children with T1D.

Methods

Children with T1D following in diabetic clinic have been prospectively screened for presence of CD, over a two-year period (2008–2010), by doing anti-TTG, EMA, and total IgA. Children with positive anti-TTG titres (>50 U/ml) and/or EMA and children with persistently low positive anti-TTG titres (two readings 20–50 U/ml; within 6 months intervals) had upper endoscopy and 6 duodenal biopsies.

Results

One hundred and six children with T1D have been screened for CD: age ranged between 8 months to 15.5 years (62 females). Nineteen children had positive anti-TTG and/or EMA, however only 12 children had biopsy proven CD (11.3%). Five of 12 had gastrointestinal symptoms (42%). Children with T1D and CD had significantly lower serum iron than children with T1D alone (8.5 μgm/L Vs 12.5 μgm/L; P = 0.014). The sensitivity and specificity of anti-TTG were 91.6% and 93.6%, with a positive and negative predictive value of 64.7% and 98.8%, respectively. Receiver operated characteristics analysis for the best cut-off value of anti-TTG level for diagnosis of CD was 63 units (sensitivity 100% and specificity 98.8%).

Conclusion

CD is highly prevalent among Saudi children with T1D. Anti-TTG titres more than 3 times the upper limit of normal has very high sensitivity and specificity for diagnosis of CD in T1D children.

Keywords:
Celiac disease; Type 1 diabetes; Anti-tissue transglutaminase; Ednomyseal antibody; Saudi Arabia