Table 5

Genotype frequencies of GNB1 single nucleotide polymorphisms stratified by gender in HCV-1 and HCV-2 infected patients receiving PEG-IFNα-RBV therapy with and without a RVR in a Chinese population in Taiwan
HCV-1 HCV-2
SNP ID RVR (+) N (%) RVR (−) N (%) Pvalue OR (95% CI) SNP ID RVR (+) N (%) RVR (−) N (%) Pvalue OR (95% CI)
rs10907185 rs10907185
Males Males
A/A 6 (10.9) 2 (2.8) 4.32 (0.81, 23.17) A/A 8 (10.7) 0 (0.0) -
A/G 24 (43.6) 36 (48.6) 0.96 (0.46, 1.98) A/G 27 (36.0) 6 (46.2) 0.79 (0.24, 2.60)
G/G 25 (45.5) 36 (48.6) 0.1600 1 G/G 40 (53.3) 7 (53.8) 0.4292 1
A/A + A/G 30 (54.5) 38 (51.4) 0.7193 1.14 (0.56, 2.29) A/A + A/G 35 (46.7) 6 (46.2) 0.9727 1.02 (0.31, 3.33)
Females Females
A/A 4 (7.6) 3 (3.6) 2.19 (0.46, 10.52) A/A 5 (6.0) 3 (12.5) 0.66 (0.14, 3.07)
A/G 21 (39.6) 34 (41.0) 1.01 (0.49, 2.08) A/G 35 (42.2) 4 (16.7) 3.46 (1.07, 11.22)
G/G 28 (52.8) 46 (55.4) 0.5986 1 G/G 43 (51.8) 17 (70.8) 0.0618 1
A/A + A/G 25 (47.2) 37 (44.6) 0.7673 1.11 (0.56, 2.22) A/A + A/G 40 (48.2) 7 (29.2) 0.0981 2.26 (0.85, 6.02)
rs6603797 rs6603797
Males Males
C/C 45 (81.8) 50 (67.6) - C/C 60 (80.0) 12 (92.3) -
C/T 9 (16.4) 24 (32.4) - C/T 15 (20.0) 1 (7.7) -
T/T 1 (1.8) 0 (0.0) 0.0672 1 T/T 0 (0.0) 0 (0.0) - 1
C/C + C/T 54 (98.2) 74 (100.0) 0.2442 - C/C + C/T 75 (100.0) 13 (100.0) - -
Females Females
C/C 42 (79.2) 66 (79.5) 1.91 (0.19, 18.97) C/C 69 (83.1) 19 (79.2) 1.82 (0.16, 21.12)
C/T 10 (18.9) 14 (16.9) 2.14 (0.19, 23.72) C/T 12 (14.5) 4 (16.6) 1.50 (0.11, 21.31)
T/T 1 (1.9) 3 (3.6) 0.8179 1 T/T 2 (2.4) 1 (4.2) 0.8601 1
C/C + C/T 52 (98.1) 80 (96.4) 0.5609 1.95 (0.20, 19.26) C/C + C/T 81 (97.6) 23 (95.8) 0.6461 1.76 (0.15, 20.30)
rs4648727 rs4648727
Males Malesa
A/A 4 (7.3) 5 (6.8) 1.20 (0.29, 5.02) A/A 9 (12.0) 0 (0.0) -
A/C 31 (56.4) 39 (52.7) 1.19 (0.57, 2.49) A/C 39 (52.0) 5 (41.7) 2.02 (0.58, 7.05)
C/C 20 (36.3) 30 (40.5) 0.8905 1 C/C 27 (36.0) 7 (58.3) 0.2255 1
A/A + A/C 35 (63.6) 44 (59.5) 0.6301 1.19 (0.58, 2.45) A/A + A/C 48 (64.0) 5 (41.7) 0.1410 2.49 (0.72, 8.61)
Femalesa Females
A/A 6 (11.4) 9 (11.0) 0.79 (0.25, 2.48) A/A 7 (8.4) 4 (16.7) 0.78 (0.20, 3.04)
A/C 19 (35.8) 40 (48.8) 0.56 (0.27, 1.18) A/C 40 (48.2) 4 (16.7) 4.44 (1.36, 14.53)
C/C 28 (52.8) 33 (40.2) 0.3067 1 C/C 36 (43.4) 16 (66.6) 0.0202* 1
A/A + A/C 25 (47.2) 49 (59.8) 0.1513 0.60 (0.30, 1.21) A/A + A/C 47 (56.6) 8 (33.3) 0.0443* 2.61 (1.01, 6.77)
rs12126768 rs12126768
Males Males
G/G 3 (5.5) 3 (4.1) 1.06 (0.20, 5.59) G/G 2 (2.7) 0 (0.0) -
G/T 17 (30.9) 34 (45.9) 0.53 (0.25, 1.11) G/T 31 (41.3) 4 (30.8) 1.66 (0.47, 5.89)
T/T 35 (63.6) 37 (50.0) 0.2244 1 T/T 42 (56.0) 9 (69.2) 0.6089 1
G/G + G/T 20 (36.4) 37 (50.0) 0.1230 0.57 (0.28, 1.17) G/G + G/T 33 (44.0) 4 (30.8) 0.3723 1.77 (0.50, 6.25)
Femalesa Females
G/G 3 (5.7) 6 (7.3) 0.62 (0.14, 2.65) G/G 4 (4.8) 4 (16.7) 0.34 (0.08, 1.52)
G/T 16 (30.2) 34 (41.5) 0.58 (0.28, 1.23) G/T 32 (38.6) 4 (16.7) 2.72 (0.83, 8.90)
T/T 34 (64.1) 42 (51.2) 0.3339 1 T/T 47 (56.6) 16 (66.6) 0.0350* 1
G/G + G/T 19 (35.8) 40 (48.8) 0.1391 0.59 (0.29, 1.19) G/G + G/T 36 (43.4) 8 (33.4) 0.3786 1.53 (0.59, 3.97)

a: Contains 1 missing data point in the RVR (−) group.

Abbreviations: SNP, single nucleotide polymorphism; RVR, rapid virological response; OR, odds ratio; CI, confidence interval.

Genotype frequencies were determined by χ2 test using 2 × 3 or 2 × 2 tables as appropriate. Odds ratios and 95% CI per genotype were estimated by unconditional logistic regression. P values less than 0.05 were considered statistically significant, and are denoted with an asterisk.

Lim et al.

Lim et al. BMC Gastroenterology 2012 12:167   doi:10.1186/1471-230X-12-167

Open Data