Open Access Open Badges Research article

Serum parameters in the spectrum of coeliac disease: beyond standard antibody testing - a cohort study

Greetje J Tack1*, Roy L J van Wanrooij1, B Mary E Von Blomberg2, Hedayat Amini2, Veerle M H Coupe3, Petra Bonnet2, Chris J J Mulder1 and Marco W J Schreurs24

Author Affiliations

1 Department of Gastroenterology and Hepatology, VU University Medical Centre, PO Box 7057, Amsterdam 1007 MB, The Netherlands

2 Department of Pathology, VU University Medical Centre, Amsterdam The Netherlands

3 Department of Epidemiology and Biostatistics, VU University Medical Centre, Amsterdam The Netherlands

4 Department of Immunology, Erasmus MC, University Medical Centre, Rotterdam, The Netherlands

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BMC Gastroenterology 2012, 12:159  doi:10.1186/1471-230X-12-159

Published: 12 November 2012



Invasive techniques are still required to distinguish between uncomplicated and complicated forms of CD.


We set out to investigate the potential use of novel serum parameters, including IL-6, IL-8, IL-17, IL-22, sCD25, sCD27, granzyme-B, sMICA and sCTLA-4 in patients diagnosed with active CD, CD on a GFD, Refractory coeliac disease (RCD) type I and II, and enteropathy associated T-cell lymphoma (EATL).


In both active CD and RCDI-II elevated levels of the proinflammatory IL-8, IL-17 and sCD25 were observed. In addition, RCDII patients displayed higher serum levels of soluble granzyme-B and IL-6 in comparison to active CD patients. In contrast, no differences between RCDI and active CD or RCDII were observed. Furthermore, EATL patients displayed higher levels of IL-6 as compared to all other groups.


A series of novel serum parameters reveal distinctive immunological characteristics of RCDII and EATL in comparison to uncomplicated CD and RCDI.

Coeliac disease; Refractory coeliac disease; Enteropathy associated T-cell lymphoma; Cytokines; Immunological and biochemical parameters