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Open Access Research article

Serum parameters in the spectrum of coeliac disease: beyond standard antibody testing - a cohort study

Greetje J Tack1*, Roy L J van Wanrooij1, B Mary E Von Blomberg2, Hedayat Amini2, Veerle M H Coupe3, Petra Bonnet2, Chris J J Mulder1 and Marco W J Schreurs24

Author Affiliations

1 Department of Gastroenterology and Hepatology, VU University Medical Centre, PO Box 7057, Amsterdam 1007 MB, The Netherlands

2 Department of Pathology, VU University Medical Centre, Amsterdam The Netherlands

3 Department of Epidemiology and Biostatistics, VU University Medical Centre, Amsterdam The Netherlands

4 Department of Immunology, Erasmus MC, University Medical Centre, Rotterdam, The Netherlands

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BMC Gastroenterology 2012, 12:159  doi:10.1186/1471-230X-12-159

Published: 12 November 2012

Abstract

Background

Invasive techniques are still required to distinguish between uncomplicated and complicated forms of CD.

Methods

We set out to investigate the potential use of novel serum parameters, including IL-6, IL-8, IL-17, IL-22, sCD25, sCD27, granzyme-B, sMICA and sCTLA-4 in patients diagnosed with active CD, CD on a GFD, Refractory coeliac disease (RCD) type I and II, and enteropathy associated T-cell lymphoma (EATL).

Results

In both active CD and RCDI-II elevated levels of the proinflammatory IL-8, IL-17 and sCD25 were observed. In addition, RCDII patients displayed higher serum levels of soluble granzyme-B and IL-6 in comparison to active CD patients. In contrast, no differences between RCDI and active CD or RCDII were observed. Furthermore, EATL patients displayed higher levels of IL-6 as compared to all other groups.

Conclusions

A series of novel serum parameters reveal distinctive immunological characteristics of RCDII and EATL in comparison to uncomplicated CD and RCDI.

Keywords:
Coeliac disease; Refractory coeliac disease; Enteropathy associated T-cell lymphoma; Cytokines; Immunological and biochemical parameters