Table 3

Changes in reported consumption of pharmaceutical agents among coeliac disease patients (pills per month on average) between the year prior to and following the diagnosis of coeliac disease
All Female Male
n = 700 n = 534 n = 166
All on-demand medicines*
  Year prior to diagnosis 12.0 12.2 11.4
  Year after diagnosis on a GFD 9.3 9.1 10.0
  Mean change (95% CI) −2.7 (−4.3 to −1.2) −3.1 (−4.9 to −1.4) −1.4 (−4.8 to 2.0)
  P value <0.001 <0.001 0.011
Painkillers
  Year prior to diagnosis 6.8 7.2 5.6
  Year after diagnosis on a  GFD 5.5 5.2 6.4
  Mean change (95% CI) −1.3 (−2.6 to −0.1) −2.0 (−3.4 to −0.5) 0.8 (−2.1 to 3.7)
  P value <0.001 <0.001 0.432
Medicines for dyspepsia
  Year prior to diagnosis 3.7 3.5 4.4
  Year after diagnosis on a GFD 2.5 2.4 2.6
  Mean change (95% CI) −1.27 (−2.10 to −0.44) −1.1 (−2.0 to −1.2) −1.8 (−3.7 to 0.1)
  P value <0.001 <0.001 0.015
Antibiotic treatment
  Year prior to diagnosis 0.6 0.7 0.4
  Year after diagnosis on a GFD 0.5 0.5 0.3
  Mean change (95% CI) −0.1 (−0.2 to −0.1) −0.2 (−0.3 to −0.1) −0.1 (−0.3 to 0.1)
  P value 0.001 0.001 0.302
Vitamins, micronutrients, herbal products
  Year prior to diagnosis 18.4 20.7 10.8
  Year after diagnosis on a  GFD 22.6 24.6 16.2
  Mean change (95% CI) 4.2 (1.8 to 6.7) 3.9 (0.9 to 6.8) 5.5 (1.8 to 9.1)
  P value <0.001 0.003 0.002

CI confidence interval.

GFD gluten-free diet.

* Painkillers, medicines for dyspepsia, sleeping pills.

Not reported as pills per month but as number of courses per year.

Ukkola et al.

Ukkola et al. BMC Gastroenterology 2012 12:136   doi:10.1186/1471-230X-12-136

Open Data