Table 7

Variables associated with and independent predictors of low adiponectin serum levels (<6 μg/ml) in 261 CHC patients
Adiponectin Low (n = 72) High (n = 189) p OR * (95% c.i.) p *
Steatosis present 59 (82) 120 (63) 0.004 3.85 (1.78-8.91) 0.0005
Age (years) 51±14 61±13 <0.0001 0.95 (0.92-0.97) <0.0001
Sex (F) 10 (14) 100 (53) <0.0001 0.18 (0.08-0.38) <0.0001
HDL (mg/dl) 42±11 53±17 <0.0001 - -
Triglycerides (mg/dl) 121±71 98±38 0.012 - -
Cirrhosis 15 (21) 65 (34) 0.036 0.65 (0.30-1.40) 0.277
Viral genotype 4 11 (15) 8 (4) 0.0055 1.68 (0.55-5.70) 0.456
ADIPOQ
rs2241766TT and rs1501299T+ 26 (36) 92 (49) 0.068 0.74 (0.39-1.40) 0.355
rs2241766G + or rs1501299GG 46 (64) 97 (51) reference
PNPLA3 rs738409
CC (148 I/I) 34 (47) 99 (52) 0.73 1.15 (0.71-2.80) 0.600
CG (148 I/M) 30 (42) 73 (39)
GG (148 M/M) 8 (11) 17 (9)

():% values; * OR of low adiponectin values at logistic regression analysis considering as independent variables the presence or not of NAFLD, age, gender, BMI, ALT, and ADIPOQ and PNPLA3 genotype (additive model; OR per number of 148 M alleles).

Valenti et al.

Valenti et al. BMC Gastroenterology 2012 12:111   doi:10.1186/1471-230X-12-111

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