Table 4

Factors associated with false positivity in patients with METAVIR F1, F2 and F3
Variable Non FP FP OR(95% CI) Pvalue
n = 77 n = 32
Age, year 50.8(1.4) 53.4(2.0) .316
Gender, male/female (n) 35/42 16/16 .679
BMI, kg/m2 24.34(0.37) 25.37(0.68) .155
HCV genotype, 1/non-1 (n) 38/39 15/17 .836
HCV RNA, x 106, copies/mL 7.14(1.12) 10.61(3.12) .194
ALT, IU/L 83.01(9.40) 133.88(15.02) .004
ALT/ULN (n)
<1x 24 2 reference
≧1x <2x 25 10 4.8(0.9-24.2) .057
≧2x <3x 16 5 3.8(0.6-21.7) .140
≧3x 12 15 15.0(2.9-76.6) .001*
ActiTest A score (n) .
0.00-0.35 31 2 reference
0.36-0.75 24 13 8.4(1.7-40.8) .008*
0.76-1.00 22 17 11.9(2.5-57.2) .002*
Bilirubin, umol/L 15.76(0.56) 19.30(1.12) .002
Cr, umol/L 70.82(2.82) 74.14(4.55) .817
INR 1.00(0.01) 1.05(0.02) .007
Na, meq/L 137.94(0.28) 137.81(0.46) .527
Platelet, x 109/L 184.21(6.20) 158.31(9.37) .025
METAVIR F1/2/3 (n) 38/32/7 8/8/16 <.001
METAVIR A (n)
A0 28 3 reference
A1 45 15 3.1(0.8-11.7) .094
A2-3 4 14 32.7(6.4-166.5) <.001*
Hepatic steatosis S0/1/2/3/4(n) 10/28/35/3/1 5/9/17/1/0 .903
Liver SWV, m/s 1.34(0.03) 2.40(0.11) <.001
FibroTest, F score 0.51(0.03) 0.72(0.04) <.001

Thirty-two patients of the 109 patients with METAVIR F1, F2 and F3 were false positive (32/109, 29%) in liver fibrosis evaluation using acoustic radiation force impulse elastography. False positive case numbers were: 8 (8/46, 17%) (ARFI LSM > 1.55 m/s) in METAVIR F1; 8 (8/40, 25%) (LSM > 1.81 m/s) in F2; 16 (16/23, 70%) (LSM > 1.98 m/s) in F3 stages. Continuous variables were presented as mean (standard error) and examined using the Student’s t-test. Categorical variables were estimated using Fisher's exact test or univariate binary logistic regression*. ALT, serum alanine aminotransferase; ARFI, acoustic radiation force impulse; CI, confidence interval; Cr, serum creatinine; FP, false positivity; INR, international normalized ratio of prothrombin time; LSM, liver stiffness measurement; METAVIR A, activity; METAVIR F, fibrosis; Na, serum sodium; non FP, true positive + true negative + false negative; OR, odds ratio; SWV, shear wave velocity.

Chen et al.

Chen et al. BMC Gastroenterology 2012 12:105   doi:10.1186/1471-230X-12-105

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