Table 2

The diagnostic performance of liver SWV and FibroTest in classifying METAVIR fibrosis (F) stages
METAVIR
F1vsF2-4 F1-2vsF3-4 F1-3vsF4
Liver SWV
AUC (95% CI) 0.847(0.779-0.914) 0.902 (0.835-0.970) 0.831 (0.723-0.939)
SE of AUC 0.034 0.035 0.055
Cutoff (m/s) 1.55 1.81 1.98
Sensitivity 74.1% 90.2% 88.9%
Specificity 87.0% 89.5% 79.8%
PPV 90.9% 80.4% 42.1%
NPV 65.6% 95.0% 97.8%
Concordance 78.8% 89.7% 81.1%
Discordance 21.2% 10.3% 18.9%
+LR 5.7 8.6 4.4
-LR 0.3 0.1 0.1
DOR(95% CI) 19.0(7.1-51.3) 79.1(22.9-273.8) 31.6(6.8-147.9)
FibroTest
AUC (95% CI) 0.823(0.748-0.898) 0.812 (0.735-0.888) 0.757 (0.648-0.865)
SE of AUC 0.038 0.039 0.055

Concordance = (true positive n + true negative n)/127, and discordance = (false positive n + false negative n)/127; AUC, area under the receiver operating characteristic curve; DOR, diagnostic odds ratio; LR, likelihood ratio; NPV, negative predictive value; PPV, positive predictive value; SE, standard error; SWV, shear wave velocity.

Chen et al.

Chen et al. BMC Gastroenterology 2012 12:105   doi:10.1186/1471-230X-12-105

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