Table 5

Diagnostic accuracy of the ALP, bilirubin, albumin, platelet count and fibrosis-cirrhosis index (FCI) for the prediction of F0-F1 stage and hepatic cirrhosis in chronic HCV infected patients (n = 157)

Marker Cutoff

Interpretation

AUC [95% CI]

Spe%

Sen%

PPV%

NPV%


ALP


< 120

F0-F1 (n = 68)

F2-F4 (n = 89)

0.829 [0.760-0.897]

69.6

85.2

68.2

86.1


58/10

27/62


> 240

F4 (n = 21)

F0-F3 (n = 136)

0.931 [0.882-0.981]

91.9

80.9

60.7

96.9


17/4

11/125


Bilirubin


< 0.95

F0-F1 (n = 68)

F2-F4 (n = 89)

0.729 [0.643-0.815]

68.1

85.2

67.4

85.7


58/10

28/60


> 1.5

F4 (n = 21)

F0-F3 (n = 136)

0.889 [0.816-0.962]

95.5

66.6

70

94.8


14/7

6/130


Albumin


> 4.1

F0-F1 (n = 68)

F2-F4 (n = 89)

0.812 [0.738-0.886]

67.4

100

70.1

100


68/0

29/60


< 3.85

F4 (n = 21)

F0-F3 (n = 136)

0.879 [0.796-0.962]

92.6

71.4

60

95.4


15/6

10/126


Platelet count


> 150

F0-F1 (n = 68)

F2-F4 (n = 89)

0.935[0.900-0.970]

69.6

98.5

71.2

98.4


67/1

27/62


< 100

F4 (n = 21)

F0-F3 (n = 136)

0.990[0.977-1.002]

98.5

80.9

89.4

97.1


17/4

2/134


FCI


< 0.130

F0-F1 (n = 68)

F2-F4 (n = 89)

0.932[0.895-0.969]

86.5

80.8

82.1

85.5


55/13

12/77


> 1.25

F4 (n = 21)

F0-F3 (n = 136)

0.996[0.989-1.002]

100

85.7

100

97.8


18/3

0/136


Spearman rank correlation coefficient (R-index) for ALP = 0.716, bilirubin = 0.597, albumin = -0.700, platelet count = -0.817 and FCI = 0.818.

Ahmad et al. BMC Gastroenterology 2011 11:44   doi:10.1186/1471-230X-11-44

Open Data