Table 1

NARANJO ADR PROBABILITY SCALE calculated for our case summed up 9 points, indicating a very probable association between acute pericarditis and interferon treatment

Question

Response

Points


Are there previous conclusion reports on this reaction?

Yes

+ 1

Did the adverse event appear after the suspect drug was administered?

Yes

+2

Did the AR improve when the drug was discontinued or a specific antagonist was administered?

Yes

+ 1

Did the AR reappear when drug was readministered?

Yes

+ 2

Are there alternate causes [other than the drug] that could solely have caused the reaction?

No

+2

Did the reaction reappear when a placebo was given?

don't know

0

Was the drug detected in the blood [or other fluids] in a concentration known to be toxic?

No

0

Was the reaction more severe when the dose was increased, or less severe when the dose was decreased?

don't know

0

Did the patient have a similar reaction to the same or similar drugs in any previous exposure?

No

0

Was the adverse event confirmed by objective evidence?

Yes

+ 1

Total

9


Popescu et al. BMC Gastroenterology 2011 11:30   doi:10.1186/1471-230X-11-30

Open Data