Table 2

Symptoms and quality of life

Screen-detected celiac patients

At the diagnosis After gluten-free diet

p-valuea

Non-celiac controls

p-value b


GSRS c

Diarrhea

2.1 (1.7-2.6)

1.5 (1.2-1.9)

0.009

1.6 (1.5-1.8)

0.091

Indigestion

2.8 (2.4-3.2)

2.0 (1.6-2.3)

< 0.001

2.4 (2.0-2.7)

0.117

Constipation

2.1 (1.7-2.5)

1.8 (1.5-2.1)

0.343

2.0 (1.6-2.3)

0.813

Abdominal pain

2.1 (1.7-2.4)

1.7 (1.4-2.0)

0.020

1.8 (1.5-2.1)

0.203

Reflux

1.8 (1.4-2.2)

1.4 (1.2-1.7)

0.040

1.5 (1.8-1.2)

0.161

Total score

2.2 (1.9-2.5)

1.7 (1.5-2.0)

0.001

1.9 (1.7-2.1)

0.133

PGWBd

Anxiety

23 (21-24)

24 (22-25)

0.256

25 (24-26)

0.063

Depression

16 (15-17)

16 (15-17)

0.429

16 (16-17)

0.713

Well-being

16 (15-17)

17 (16-18)

0.011

17 (16-17)

0.364

Self-control

15 (14-16)

15 (14-16)

0.942

15 (15-16)

0.593

General health

13 (12-14)

12 (11-14)

0.243

14 (14-15)

0.030

Vitality

17 (16-18)

18 (16-19)

0.100

19 (18-19)

0.110

Total score

100 (93-106)

102 (95-109)

0.620

106 (104-108)

0.355


Gastrointestinal symptom score (GSRS) and psychological general well-being (PGWB) in older celiac disease patients before and after dietary treatment, compared to non-celiac controls

a Comparison between celiac patients at the diagnosis and after gluten-free diet

b Comparison between celiac patients at the diagnosis and non-celiac controls

c Gastrointestinal symptom rating scale; higher scores indicate more gastro-intestinal symptoms

d Psychological general well-being; higher scores indicate better quality of life

Vilppula et al. BMC Gastroenterology 2011 11:136   doi:10.1186/1471-230X-11-136

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