Survival of GC-C KO mice following acute CCl4 injury. Mice were injected intraperitoneally with 1 μl CCl4 per gram body weight as a 50% solution in corn oil and checked daily for 2 weeks. (A) In the outbred Black Swiss F2 generation, 65% of WT littermates survived while only 1 GC-C null mouse was alive at Day 14 post-injection. (P = 0.0008, N = 19 WT mice, N = 30 GC-C null mice). (B) No difference in survival is seen between the 2 genotypes in the C57BL/6 J background. N = 12 mice per group.
Mann et al. BMC Gastroenterology 2010 10:86 doi:10.1186/1471-230X-10-86