Histopathological examination of mouse livers by Sirius red staining. Sirius red staining of the liver from all control mice at each time point revealed normal lobular architecture and a normal distribution of collagen (upper). Sirius red staining of liver tissue from CCl4 Group at Time point II revealed extensive collagen deposition and pseudolobular formation, indicative of bridging fibrosis (bottom middle). The degree of collagen deposition decreased at Time point III (bottom right). (original magnification ×40).
Fujii et al. BMC Gastroenterology 2010 10:79 doi:10.1186/1471-230X-10-79