Table 3

Effects of omeprazole on patients with GERD Group III (n = 9)

Pretreatment with omeprazole

4 weeks Post treatment with omeprazole

8 weeks Post treatment with omeprazole


A) Symptoms:

1-Heart burn:

Yes

7

2 (71.4%)

0 (100%)

Duration(months)

1.2 ± 0.3


2-Epigastric pain:

Yes

6

2

0

Duration(months)

1.3 ± 0.4

(66.7%)

(100%)


B)LES Study:

1-LES pressure(mmHg)

10.5 ± 2.86

10.4 ± 4.05

10.5 ± 2.85


2-Residual pressure (mmHg)

0.1 ± 0.064

0.2 ± 0.15

0.1 ± 0.07


3-Relaxation duration (seconds)

6.5 ± 2.74

6.3 ± 2.7

6.3 ± 2.65


4-Relaxation %

87.2 ± 0.17

87.3 ± 0.25

87.1 ± 0.1


C) PH (at 5 cm above the LES):

2.1 ± 0.38

5.9 ± 0.48a

7.2 ± 0.32ab


D) BAO (mmol/h)

25.1 ± 0.6

17.2 ± 0.7a

11.5 ± 0.6ab


E) Serum Gastrin (pg/ml)

21.5 ± 4.6

32.1 ± 2.1a

35.9 ± 1.8ab


D) Melatonin level at day time (pg/ml):

18.5 ± 3.75

19.2 ± 3.47

17.9 ± 3.72


a: p < 0.05 relative to pretreatment with melatonin

b: p < 0.05 relative to 4 weeks Post treatment with melatonin

Kandil et al. BMC Gastroenterology 2010 10:7   doi:10.1186/1471-230X-10-7

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