Email updates

Keep up to date with the latest news and content from BMC Family Practice and BioMed Central.

Open Access Highly Accessed Research article

House dust mite barrier bedding for childhood asthma: randomised placebo controlled trial in primary care [ISRCTN63308372]

Aziz Sheikh1*, Brian Hurwitz1, Bonnie Sibbald2, Greta Barnes3, Maggie Howe3 and Stephen Durham4

Author Affiliations

1 Department of Primary Health Care & General Practice, Imperial College of Science, Technology & Medicine, London, UK

2 National Primary Care Research & Development Centre, University of Manchester, Manchester, UK

3 National Respiratory Training Centre, Warwick, UK

4 Upper Respiratory Medicine, Imperial College of Science, Technology & Medicine, London, UK

For all author emails, please log on.

BMC Family Practice 2002, 3:12  doi:10.1186/1471-2296-3-12

Published: 18 June 2002

Abstract

Background

The house dust mite is the most important environmental allergen implicated in the aetiology of childhood asthma in the UK. Dust mite barrier bedding is relatively inexpensive, convenient to use, and of proven effectiveness in reducing mattress house dust mite load, but no studies have evaluated its clinical effectiveness in the control of childhood asthma when dispensed in primary care. We therefore aimed to evaluate the effectiveness of house dust mite barrier bedding in children with asthma treated in primary care.

Methods

Pragmatic, randomised, double-blind, placebo controlled trial conducted in eight family practices in England. Forty-seven children aged 5 to 14 years with confirmed house dust mite sensitive asthma were randomised to receive six months treatment with either house dust mite barrier or placebo bedding. Peak expiratory flow was the main outcome measure of interest; secondary outcome measures included asthma symptom scores and asthma medication usage.

Results

No difference was noted in mean monthly peak expiratory flow, asthma symptom score, medication usage or asthma consultations, between children who received active bedding and those who received placebo bedding.

Conclusions

Treating house dust mite sensitive asthmatic children in primary care with house dust mite barrier bedding for six months failed to improve peak expiratory flow. Results strongly suggest that the intervention made no impact upon other clinical features of asthma.