Open Access Highly Accessed Research article

The association of metabolic syndrome and its factors with gallstone disease

I-Ching Lin123, Yu-Wen Yang1, Mei-Feng Wu4, Yi-Hui Yeh5, Jenn-Chang Liou2, Ying-Li Lin1 and Chih-Hsiang Chiang1*

Author Affiliations

1 Family Medicine Department, Changhua Christian Hospital, No. 135, St. Nan-Xiao, Changhua City 500, Taiwan

2 Department of Healthcare Administration, Asia University, Taichung City, Taiwan

3 School of Medicine, Chung Shan Medical University, Taichung City, Taiwan

4 Health Examination Department, Changhua Christian Hospital, Changhua City, Taiwan

5 Institute of Statistics, National Chung Hsing University, Taichung City, Taiwan

For all author emails, please log on.

BMC Family Practice 2014, 15:138  doi:10.1186/1471-2296-15-138

Published: 29 July 2014



To investigate the association between metabolic syndrome, including its factors, and gallstone disease (GSD) in a Taiwanese population.


We conducted a cross-sectional study during 2011 ~ 2012. A total of 12050 subjects who completed a questionnaire and underwent physical examination, laboratory tests and abdominal ultrasonography formed the study population.


The prevalences of metabolic syndrome and gallstone disease were 24.09% and 6.16%. In an age- and sex-adjusted logistic regression model, metabolic syndrome was associated with gallstone disease (OR = 1.61; P < 0.0001). Age, abdominal obesity, and lower high-density lipoprotein cholesterol were associated with gallstone disease after adjusting for other factors. Females had a higher odds ratio than males in waist circumference for GSD, whereas males had a lower odds ratio than females in HDL-C for GSD.


The present study suggests that metabolic syndrome is related to gallstone disease. Waist circumference and high-density lipoprotein cholesterol are all associated with GSD. Men and women may possibly have different priorities and strategies to reduce the burden of GSD.

Obesity; Dyslipidemia; Metabolic factors; Metabolic syndrome; Gallstone disease