Email updates

Keep up to date with the latest news and content from BMC Family Practice and BioMed Central.

Open Access Highly Accessed Research article

The association of metabolic syndrome and its factors with gallstone disease

I-Ching Lin123, Yu-Wen Yang1, Mei-Feng Wu4, Yi-Hui Yeh5, Jenn-Chang Liou2, Ying-Li Lin1 and Chih-Hsiang Chiang1*

Author Affiliations

1 Family Medicine Department, Changhua Christian Hospital, No. 135, St. Nan-Xiao, Changhua City 500, Taiwan

2 Department of Healthcare Administration, Asia University, Taichung City, Taiwan

3 School of Medicine, Chung Shan Medical University, Taichung City, Taiwan

4 Health Examination Department, Changhua Christian Hospital, Changhua City, Taiwan

5 Institute of Statistics, National Chung Hsing University, Taichung City, Taiwan

For all author emails, please log on.

BMC Family Practice 2014, 15:138  doi:10.1186/1471-2296-15-138

Published: 29 July 2014



To investigate the association between metabolic syndrome, including its factors, and gallstone disease (GSD) in a Taiwanese population.


We conducted a cross-sectional study during 2011 ~ 2012. A total of 12050 subjects who completed a questionnaire and underwent physical examination, laboratory tests and abdominal ultrasonography formed the study population.


The prevalences of metabolic syndrome and gallstone disease were 24.09% and 6.16%. In an age- and sex-adjusted logistic regression model, metabolic syndrome was associated with gallstone disease (OR = 1.61; P < 0.0001). Age, abdominal obesity, and lower high-density lipoprotein cholesterol were associated with gallstone disease after adjusting for other factors. Females had a higher odds ratio than males in waist circumference for GSD, whereas males had a lower odds ratio than females in HDL-C for GSD.


The present study suggests that metabolic syndrome is related to gallstone disease. Waist circumference and high-density lipoprotein cholesterol are all associated with GSD. Men and women may possibly have different priorities and strategies to reduce the burden of GSD.

Obesity; Dyslipidemia; Metabolic factors; Metabolic syndrome; Gallstone disease