The association of metabolic syndrome and its factors with gallstone disease
1 Family Medicine Department, Changhua Christian Hospital, No. 135, St. Nan-Xiao, Changhua City 500, Taiwan
2 Department of Healthcare Administration, Asia University, Taichung City, Taiwan
3 School of Medicine, Chung Shan Medical University, Taichung City, Taiwan
4 Health Examination Department, Changhua Christian Hospital, Changhua City, Taiwan
5 Institute of Statistics, National Chung Hsing University, Taichung City, Taiwan
BMC Family Practice 2014, 15:138 doi:10.1186/1471-2296-15-138Published: 29 July 2014
To investigate the association between metabolic syndrome, including its factors, and gallstone disease (GSD) in a Taiwanese population.
We conducted a cross-sectional study during 2011 ~ 2012. A total of 12050 subjects who completed a questionnaire and underwent physical examination, laboratory tests and abdominal ultrasonography formed the study population.
The prevalences of metabolic syndrome and gallstone disease were 24.09% and 6.16%. In an age- and sex-adjusted logistic regression model, metabolic syndrome was associated with gallstone disease (OR = 1.61; P < 0.0001). Age, abdominal obesity, and lower high-density lipoprotein cholesterol were associated with gallstone disease after adjusting for other factors. Females had a higher odds ratio than males in waist circumference for GSD, whereas males had a lower odds ratio than females in HDL-C for GSD.
The present study suggests that metabolic syndrome is related to gallstone disease. Waist circumference and high-density lipoprotein cholesterol are all associated with GSD. Men and women may possibly have different priorities and strategies to reduce the burden of GSD.