Table 2

Characteristics of studies identified to date
Characteristic Sox et al.[8] Buntinx et al.[23] Nilsson et al.[27] Verdon et al.[2] Bösner et al.[28] Haasenritter et al.[29]
Data collection 1982 1988 1998-2000 2001 2005-2006 2009-2010
Country USA Belgium Sweden Switzerland Germany Germany
Setting 66 PCPs at 1 Drop-in clinic 25 PCPs 3 health care centres each served by 4 PCPs 58 PCPs in private practice 74 PCPs in private practice 56 PCPs in private practice
Number of patients 404* 323 554 672 1249 880
Inclusion criteria Chest pain as presenting complaint, no age limitation (ages were 17 to 81 years; average 41 years) New episode of chest pain, discomfort or tightness as main or ancillary complaint New episode of chest pain, discomfort or tightness as presenting complaint; aged 20–79 years; patients were excluded: if acute MI or coronary re-vascularization during the previous year Chest pain as main or ancillary complaint; age ≥ 16 years Chest pain as main or ancillary complaint; age ≥ 35 years; excluded: chest pain ≥ 1 one month, or had already been investigated Chest pain as main or ancillary complaint; age ≥ 35 years; excluded: chest pain ≥ 1 one month, or had already been investigated
No age limitation (ages were 17 to 81 years;average 41 years) No age limitation (ages were 1 to 88 years; average 45 years)
Reference standard Delayed-type reference standard Delayed-type reference standard Delayed-type reference standard Delayed-type reference standard Delayed-type reference standard Delayed-type reference standard
Duration of follow-up Average time to diagnosis: 2 months (range – to 8 months) 2 weeks to 2 months 3 months 12 months 6 months 6 months
RD established by 2 internist-investigators independently assigned diagnosis. Treating physicians Treating physicians Treating physicians Independent expert panel (1GP, 1 cardiologist, 1 research fellow) Independent expert panel (1GP, 1 research fellow)
Prevalence of CHD as cause of chest pain 7.2% 9.6% 11.2% 12.6% 14.4% 10.6%

RD reference diagnosis, MI myocardial infarction, PCP primary care physician.

*The number of patients is greater than as previously reported [8] because it includes patients excluded in the published study (diagnosis was acute MI, first episode of chest pain).

Haasenritter et al.

Haasenritter et al. BMC Family Practice 2012 13:81   doi:10.1186/1471-2296-13-81

Open Data