Table 3 |
|||||
|
Results of Meta-Analysis Evaluating the Association Between Prescriber and Patient Characteristics and Warfarin Use |
|||||
|
Characteristic |
N Studies |
Pooled OR (95%CI) |
I2 |
Qp |
Egger's p |
|
|
|||||
|
Advancing (dichotomous) age* |
11 |
0.57 (0.39-0.82) |
79% |
< 0.0001 |
0.40 |
|
|
|||||
|
Age per 10 year increase |
4 |
0.78 (0.68-0.90) |
70% |
0.02 |
0.20 |
|
|
|||||
|
Alcohol or drug abuse |
2 |
0.62 (0.40-0.96) |
NA |
0.72 |
NA |
|
|
|||||
|
Coronary artery disease |
3 |
1.08 (0.82-1.42) |
39% |
0.20 |
NA |
|
|
|||||
|
Congestive heart failure |
8 |
1.36 (1.18-1.57) |
84% |
< 0.0001 |
0.60 |
|
|
|||||
|
Contraindications to warfarin |
3 |
0.81 (0.69-0.96) |
0% |
0.58 |
NA |
|
|
|||||
|
Cerebral vascular accident |
10 |
1.58 (1.15-2.18) |
93% |
< 0.0001 |
0.84 |
|
|
|||||
|
Dementia |
3 |
0.32 (0.14-0.75) |
78% |
0.01 |
NA |
|
|
|||||
|
Diabetes |
2 |
1.11 (0.97-1.26) |
NA |
0.52 |
NA |
|
|
|||||
|
Falls |
4 |
0.60 (0.43-0.85) |
83% |
0.0006 |
0.25 |
|
|
|||||
|
Gastrointestinal bleeding |
3 |
0.47 (0.40-0.55) |
0% |
0.51 |
NA |
|
|
|||||
|
History of bleeding |
3 |
0.47 (0.21-1.03) |
80% |
0.007 |
NA |
|
|
|||||
|
Hepatic impairment |
2 |
0.59 (0.50-0.70) |
NA |
> 0.99 |
NA |
|
|
|||||
|
Hypertension |
5 |
1.34 (0.99-1.81) |
91% |
< 0.0001 |
0.48 |
|
|
|||||
|
Intracranial bleeding |
3 |
0.39 (0.28-0.55) |
2% |
0.36 |
NA |
|
|
|||||
|
Male gender |
11 |
1.12 (1.04-1.21) |
58% |
0.008 |
0.17 |
|
|
|||||
|
Perceived barriers to compliance |
2 |
0.87 (0.76-0.99) |
NA |
0.32 |
NA |
|
|
|||||
|
Renal impairment |
6 |
0.69 (0.60-0.80) |
70% |
0.005 |
0.40 |
|
|
|||||
|
N = number of studies; NA = not available/applicable; OR = odds ratio; Qp = Q statistic p-value *Advancing age analysis included any study reporting the odds of warfarin use dichotomously stratified by age. Age of stratification may have been 65, 75, or 80 years of age and was not disclosed in one study |
|||||
|
Baczek et al. BMC Family Practice 2012 13:5 doi:10.1186/1471-2296-13-5 |
|||||
