Table 1

Viral, genetic, and autoimmune diseases of the liver (tested for by a "liver panel"), their prevalence in the British population and diagnostic algorithms.*

Disease

Prevalence amongst adult population (%)

Blood tests done on all members of the cohort (to diagnose or screen for the disease)

Diagnostic algorithm


Chronic viral hepatitis C

0.42 [46]

Hepatitis C virus antibody (HCV Ab)

Viral marker positive.


Chronic viral hepatitis B

0.3 [47]

Hepatitis B viral markers (HBV Surface Ag)

Viral marker positive.


Metal storage disease: Iron

0.25 (prevalence of phenotype; homozygous plus complex heterozygous) [48]

Iron saturation

Genotype if iron saturation >50%.


Primary biliary cirrhosis (PBC)

0.024 [49]

Antimitochondrial Ab

Raised antibodies and raised ALP level.


Autoimmune hepatitis

0.001 [50]

Smooth Muscle Ab

Raised antibodies and raised ALT, AST or globulin exceeding twice the upper limit of normal. Confirmed by hepatologist.


Metal storage disease: Copper

<0.025 [51]

Caeruloplasmin

Low levels of caeruloplasmin.


Alpha-1 antitrypsin deficiency

<0.025 [52]

Alpha-1 antitrypsin

Low Alpha-1antitrypsin levels followed by phenotype testing.


* Method by which the diagnosis was made.

Arnold et al. BMC Family Practice 2011 12:9   doi:10.1186/1471-2296-12-9

Open Data