Table 6 |
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Validation statistics for each models in the THIN and QResearch® validation cohorts |
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moderate-severe CKD |
End Stage Kidney Failure |
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|
Women |
THIN cohort |
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|
R2 statistic (%) |
56.19 (55.67 to 56.70) |
54.02 (51.67 to 56.37) |
|
|
D statistic |
2.32 (2.30 to 2.34) |
2.22 (2.11 to 2.32) |
|
|
ROC statistic |
0.875 (0.872 to 0.877) |
0.818 (0.803 to 0.833) |
|
|
QResearch cohort |
|||
|
R2 statistic (%) |
56.45 (55.40 to 57.50) |
55.39 (0.52.59 to 58.18) |
|
|
D statistic |
2.33 (2.28 to 2.40) |
2.28 (2.15 to 2.41) |
|
|
ROC statistic |
0.877 (0.873 to 0.880) |
0.843 (0.825 to 0.860) |
|
|
Men |
THIN cohort |
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|
R2 statistic (%) |
57.41 (54.56 to 60.27) |
52.86 (50.55 to 55.17) |
|
|
D statistic |
2.38 (2.24 to 2.51) |
2.17 (2.07 to 2.27) |
|
|
ROC statistic |
0.875 (0.873 to 0.878) |
0.839 (0.827 to 0.850) |
|
|
QResearch cohort |
|||
|
R2 statistic (%) |
58.29 (55.31 to 61.26) |
56.65 (53.94 to 59.35) |
|
|
D statistic |
2.42 (2.28 to 2.56) |
2.34 (2.21 to 2.47) |
|
|
ROC statistic |
0.878 (0.874 to 0.882) |
0.846 (0.829 to 0.862) |
|
|
|
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Notes on understanding validation statistics: R2 statistic shows explained variation - higher values indicate more variation is explained ROC statistic is a measure of discrimination - higher values indicate better discrimination D statistic is a measure of discrimination - higher values indicate better discrimination and an increase of 0.1 or more over other risk prediction models is a good marker of improved prognostic separation |
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Hippisley-Cox and Coupland BMC Family Practice 2010 11:49 doi:10.1186/1471-2296-11-49 |
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