|
Proposed advantages of individual patient data meta-analyses |
| Ability to use common definitions, coding and cutpoints |
| Address questions not addressed in original publication |
| Assess adequacy of randomization |
| Permits data checking |
| Permits data updating |
| Permits checking of analyses |
| Allows adjustment for the same variables across studies |
| Permits ready use of time-to-event data for estimating survival |
| Ability to address long-term outcomes |
| Facilitates exploration of heterogeneity at the patient level and subgroup analyses of patient level data |
Lyman and Kuderer BMC Medical Research Methodology 2005 5:14 doi:10.1186/1471-2288-5-14 |