Comments(1)Have something to say? Post a comment on this article! |
|
|
|
 |  | Log on / register Feedback | Support | My details |
on Google Scholar
|
|
| © 1999-2010 BioMed Central Ltd unless otherwise stated. Part of Springer Science+Business Media. |
|
|
|
| | Log on / register Feedback | Support | My details |
Comments(1)Have something to say? Post a comment on this article! |
|
|
| © 1999-2010 BioMed Central Ltd unless otherwise stated. Part of Springer Science+Business Media. |
What are multiple hypothesis tests?
Ronan Conroy (10 August 2005) Royal College of Surgeons in Ireland
A distinction needs to be made between tests of multiple hypothesis and multiple tests of the same hypothesis. If a study of treatment effectiveness uses multiple endpoints, then finding a significant effect for any of the endpoints will lead to the conclusion that the treatment is effective. For this reason, protection against a false positive conclusion has to be based on keeping the family-wise error rate to 5%.
However, many studies simultaneously test several hypotheses. I see no reason why we should penalise these designs. Replication, or failure to replicate, seem to me to offer sufficient security in these situations.
Competing interests
None
top