Table 4

Hazard ratios for statins from cox proportional hazards models for incident CHD
CHD, Hard CVD, Hard
(Events = 119) (Events = 190)
Model (N = 6035) HR (95% CI) p-value HR (95% CI) p-value
Unweighted1 0.97 (0.60,1.59) 0.915 0.92 [0.62,1.36] 0.676
Weighted
  Propensity model
  No cholesterol 0.92 [0.54,1.57] 0.767 0.82 [0.54,1.26] 0.373
  Imputed cholesterol2 0.74 [0.38,1.42] 0.363 0.72 [0.43,1.21] 0.215
  New-user analysis (N = 4886) 0.91 [0.45,1.80] (Events = 100) 0.777 0.71 [0.38,1.30] (Events = 153) 0.265
  Sensitivity analysis3
  No truncating 0.59 [0.27,1.32] 0.199 0.62 [0.34,1.15] 0.130
  <.2 & >20 0.68 [0.34,1.36] 0.275 0.69 [0.40,1.17] 0.166
  <.3 & >30 0.64 [0.30,1.34] 0.238 0.66 [0.38,1.16] 0.152
  <.3 & >10 0.74 [0.39,1.42] 0.370 0.73 [0.44,1.21] 0.220

1 Adjusted for traditional risk factors: Age, gender, race/ethnicity, BMI, diabetes status, family history of heart attack, smoking status, hypertensive medications, systolic BP.

2 Multiple imputations were used for models where imputed cholesterol was used in creating the weights. Weights < .1 were set to 0.1 and weights >10 were set to 10.

3 Using non-truncated stabilized weights and various thresholds for truncating.

Jorgensen et al.

Jorgensen et al. BMC Medical Research Methodology 2013 13:81   doi:10.1186/1471-2288-13-81

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