Table 1

Drug Effectiveness Review Project (DERP): Quality assessment criteria checklists by study design
Study design Controlled clinical trial Observational study Systematic review
Quality Assessment Criteria ·Randomization adequate? ·Non-biased selection? ·Report clear review question, state inclusion and exclusion criteria of primary studies?
· Allocation concealment adequate? ·High overall loss to follow-up or differential loss to follow-up?
·Groups similar at baseline?
·Outcomes pre-specified and defined? ·Substantial effort to find relevant research?
·Eligibility criteria specified?
·Ascertainment techniques adequately described? ·Adequate assessment of validity of included studies?
·Outcome assessors masked?
·Care provider masked? ·Non-biased and adequate ascertainment methods? ·Sufficient detail of individual studies presented?
·Patient masked?
·ITT-analysis? ·Statistical analysis of potential confounders?
·Maintenance of comparable groups? ·Primary studies summarized appropriately?
·Adequate duration of follow-up?
·Acceptable levels of crossovers, adherence, and contamination?
·Overall and between-group attrition acceptable?

Abbreviations: ITT intention-to-treat.

McDonagh et al.

McDonagh et al. BMC Medical Research Methodology 2012 12:140   doi:10.1186/1471-2288-12-140

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