Table 2 |
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|
Estimation of the final occurrence rate of the event P(E) at the end of follow-up according to the estimation method in MCAR and MAR scenarios (500 replications of samples sized 2000) |
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|
Scenario n° |
True occurrence rate of the event P(E) (%) |
Kaplan-Meier |
Multiple Imputation |
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|
|
|
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|
Estimate (a) |
Standard Error (a) |
Bias (b) |
Coverage (c) |
Estimate (a) |
Standard Error (a) |
Bias (b) |
Coverage (c) |
|||
|
|
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|
MCAR scenarios |
1 |
34.4 |
34.3 |
1.1 |
-0.04 |
94.6 |
34.4 |
1.2 |
-0.01 |
94.6 |
|
2 |
61.3 |
61.3 |
1.2 |
-0.09 |
95.6 |
61.3 |
1.2 |
-0.08 |
95.0 |
|
|
3 |
80.4 |
80.5 |
1.0 |
0.08 |
95.8 |
80.5 |
1.0 |
0.09 |
95.4 |
|
|
|
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|
MAR scenarios |
4 |
34.4 |
34.3 |
1.5 |
-0.07 |
95.2 |
34.4 |
1.8 |
0.01 |
94.4 |
|
5 |
61.3 |
56.3 |
1.6 |
-5.1 |
10.6 |
61.5 |
1.8 |
0.2 |
92.4 |
|
|
6 |
80.4 |
75.7 |
1.2 |
-4.7 |
2.6 |
80.6 |
1.1 |
0.2 |
92.2 |
|
|
7 |
61.3 |
66.2 |
1.6 |
4.9 |
14.8 |
63.0 |
1.8 |
1.6 |
85.2 |
|
|
8 |
80.4 |
87.4 |
1.5 |
7.0 |
0.2 |
82.1 |
1.8 |
1.7 |
83.4 |
|
|
|
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|
(a) mean value of the estimate and of the standard error of the 500 replications (b) difference between estimate and the true occurrence rate P(E) (c) proportion of 500 simulations-runs where the 95% Confidence Interval contained the true occurrence rate |
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|
Soullier et al. BMC Medical Research Methodology 2010 10:79 doi:10.1186/1471-2288-10-79 |
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