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This article is part of the supplement: Abstracts from the 2012 PLA Emergency Medicine Annual Congress

Open Access Meeting abstract

Studying the therapeutic effects of hemoperfusion with continuous venovenous hemofiltration in paraquat-poisoned patients by the ratio of residual normal lung in 3D-CT image

Liu Peng1, Zhang Hong-tao2, Liang Yu-guang3, He Jin1, Li Yue-qi1, Li Gong-jie2* and Zhou Yue-su1*

Author Affiliations

1 Department of Emergency, 302 Hospital of PLA, Beijing 100039, China

2 Department of Radiology, Affiliated hospital of Academy of Military Medical Sciences, Beijing 100071, China

3 Department of Pharmacology, Academy of Military Medical Sciences, Beijing 100071, China

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BMC Emergency Medicine 2012, 12(Suppl 1):A1  doi:10.1186/1471-227X-12-S1-A1

The electronic version of this article is the complete one and can be found online at: http://www.biomedcentral.com/1471-227X/12/S1/A1


Published:18 December 2012

© 2012 Peng et al; licensee BioMed Central Ltd.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Objective

Paraquat poisoning(PQ) by ingestion is often fatal and is a significant public health problem worldwide.The lung is the major target organ for PQ poisoning. The study is aimed to investigate the ratio of residual normal lung in 3D-CT image in evaluating the therapic effects of continuous venovenous hemofiltration(CVVH).

Methods

Nighty-five patients with acute paraquat poisoning were randomly divided into hemoperfusion(HP) group (46 cases) and HP-CVVH group (49 cases). The mortality, survival duration and the ratio of residual normal lung in 3D-CT image between the two groups were compared and analyzed.

Results

There were no significant differences in mortality (28.26% versus 24.49%) between the two groups on day 28 after poisoning. The mean time between poisoning and death in HP-CVVH group was (5.2±2.1) days, which was significantly longer than that (3.8±1.7) days in HP group (P<0.05). The ratio of residual normal lung in 3D-CT image on 6th day after poisoning in HP-CVVH group was (31.80±12.71)%,which was significantly higher than that (25.60±14.06)% in HP group (P < 0.05).

Conclusion

The combined therapy of HP and CVVH could prevent advances in lung injury induced by acute paraquat poisoning and prolong survival time, but failed to reduce mortality of paraquat-poisoned patients.