A multicenter, randomized controlled trial of immediate total-body CT scanning in trauma patients (REACT-2)
1 Trauma Unit Department of Surgery, Academic Medical Center, Amsterdam, The Netherlands
2 Department of Radiology, Academic Medical Center, Amsterdam, The Netherlands
3 Department of Anaesthesiology Academic Medical Center, Amsterdam, The Netherlands
4 Department of Clinical Epidemiology, Biostatistics and Bioinformatics, Academic Medical Center, Amsterdam, The Netherlands
5 Trauma Unit Department of Surgery, University Medical Center Sint Radboud, Nijmegen, The Netherlands
6 Department of Radiology and Nuclear Medicine, University Hospital Basel, Basel, Switzerland
7 Trauma Unit Department of Surgery, University Medical Center Groningen, Groningen, The Netherlands
8 Trauma Unit Department of Surgery, Erasmus Medical Center, Rotterdam, The Netherlands
9 Trauma Unit Department of Surgery, Ben Taub General Hospital, Houston, USA
BMC Emergency Medicine 2012, 12:4 doi:10.1186/1471-227X-12-4Published: 30 March 2012
Computed tomography (CT) scanning has become essential in the early diagnostic phase of trauma care because of its high diagnostic accuracy. The introduction of multi-slice CT scanners and infrastructural improvements made total-body CT scanning technically feasible and its usage is currently becoming common practice in several trauma centers. However, literature provides limited evidence whether immediate total-body CT leads to better clinical outcome then conventional radiographic imaging supplemented with selective CT scanning in trauma patients. The aim of the REACT-2 trial is to determine the value of immediate total-body CT scanning in trauma patients.
The REACT-2 trial is an international, multicenter randomized clinical trial. All participating trauma centers have a multi-slice CT scanner located in the trauma room or at the Emergency Department (ED). All adult, non-pregnant, severely injured trauma patients according to predefined criteria will be included. Patients in whom direct scanning will hamper necessary cardiopulmonary resuscitation or who require an immediate operation because of imminent death (both as judged by the trauma team leader) are excluded. Randomization will be computer assisted. The intervention group will receive a contrast-enhanced total-body CT scan (head to pelvis) during the primary survey. The control group will be evaluated according to local conventional trauma imaging protocols (based on ATLS guidelines) supplemented with selective CT scanning. Primary outcome will be in-hospital mortality. Secondary outcomes are differences in mortality and morbidity during the first year post trauma, several trauma work-up time intervals, radiation exposure, general health and quality of life at 6 and 12 months post trauma and cost-effectiveness.
The REACT-2 trial is a multicenter randomized clinical trial that will provide evidence on the value of immediate total-body CT scanning during the primary survey of severely injured trauma patients. If immediate total-body CT scanning is found to be the best imaging strategy in severely injured trauma patients it could replace conventional imaging supplemented with CT in this specific group.