Cardiac insulin-like growth factor-1 and cyclins gene expression in canine models of ischemic or overpacing cardiomyopathy

doi:10.1186/1471-2261-9-49

BMC Cardiovascular Disorders
Volume 9

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Mathieu M
Touihri K
Hadad I
Da Costa AM
Naeije R
Mc Entee K

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Research article

Cardiac insulin-like growth factor-1 and cyclins gene expression in canine models of ischemic or overpacing cardiomyopathy

Maryam Mahmoudabady¹^,2 , Myrielle Mathieu¹ , Karim Touihri¹ , Ielham Hadad¹ , Agnes Mendes Da Costa¹ , Robert Naeije¹ and Kathleen Mc Entee¹

¹Laboratory of Physiology, Faculty of Medicine, Université Libre de Bruxelles, Brussels, Belgium

²Department of Physiology, Faculty of Medicine, Mashhad University of Medical Sciences (MUMS), Mashhad, Iran

author email corresponding author email

BMC Cardiovascular Disorders 2009, 9:49doi:10.1186/1471-2261-9-49


Published:	9 October 2009

Abstract

Background

Insulin-like growth factor-1 (IGF-1), transforming growth factor β (TGFβ) and cyclins are thought to play a role in myocardial hypertrophic response to insults. We investigated these signaling pathways in canine models of ischemic or overpacing-induced cardiomyopathy.

Methods

Echocardiographic recordings and myocardial sampling for measurements of gene expressions of IGF-1, its receptor (IGF-1R), TGFβ and of cyclins A, B, D1, D2, D3 and E, were obtained in 8 dogs with a healed myocardial infarction, 8 dogs after 7 weeks of overpacing and in 7 healthy control dogs.

Results

Ischemic cardiomyopathy was characterized by moderate left ventricular systolic dysfunction and eccentric hypertrophy, with increased expressions of IGF-1, IGF-1R and cyclins B, D1, D3 and E. Tachycardiomyopathy was characterized by severe left ventricular systolic dysfunction and dilation with no identifiable hypertrophic response. In the latter model, only IGF-1 was overexpressed while IGF-1R, cyclins B, D1, D3 and E stayed unchanged as compared to controls. The expressions of TGFβ, cyclins A and D2 were comparable in the 3 groups. The expression of IGF-1R was correlated with the thickness of the interventricular septum, in systole and diastole, and to cyclins B, D1, D3 and E expression.

Conclusion

These results agree with the notion that IGF-1/IGF-1R and cyclins are involved in the hypertrophic response observed in cardiomyopathies.