Open Access Highly Accessed Research article

The CoLaus study: a population-based study to investigate the epidemiology and genetic determinants of cardiovascular risk factors and metabolic syndrome

Mathieu Firmann1, Vladimir Mayor1, Pedro Marques Vidal2, Murielle Bochud2, Alain Pécoud3, Daniel Hayoz4, Fred Paccaud2, Martin Preisig5, Kijoung S Song6, Xin Yuan6, Theodore M Danoff7, Heide A Stirnadel8, Dawn Waterworth6, Vincent Mooser6, Gérard Waeber1 and Peter Vollenweider1*

Author Affiliations

1 Department of Medicine, Internal Medicine, CHUV, Lausanne, Switzerland

2 Institute of Social and Preventive Medicine (IUMSP), University of Lausanne, Switzerland

3 Outpatient Clinic, University of Lausanne, Switzerland

4 Department of Medicine, Angiology, CHUV, Lausanne, Switzerland

5 Department of Psychiatry, CHUV, Lausanne, Switzerland

6 Medical Genetics/Clinical Pharmacology and Discovery Medicine, GlaxoSmithKline, Philadelphia PA, USA

7 Center of Excellence for Drug Discovery CV, GlaxoSmithKline, Philadelphia PA, USA

8 Worldwide Epidemiology, GlaxoSmithKline, Harlow, UK

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BMC Cardiovascular Disorders 2008, 8:6  doi:10.1186/1471-2261-8-6

Published: 17 March 2008

Abstract

Background

Cardiovascular diseases and their associated risk factors remain the main cause of mortality in western societies. In order to assess the prevalence of cardiovascular risk factors (CVRFs) in the Caucasian population of Lausanne, Switzerland, we conducted a population-based study (Colaus Study). A secondary aim of the CoLaus study will be to determine new genetic determinants associated with CVRFs.

Methods

Single-center, cross-sectional study including a random sample of 6,188 extensively phenotyped Caucasian subjects (3,251 women and 2,937 men) aged 35 to 75 years living in Lausanne, and genotyped using the 500 K Affymetrix chip technology.

Results

Obesity (body mass index ≥ 30 kg/m2), smoking, hypertension (blood pressure ≥ 140/90 mmHg and/or treatment), dyslipidemia (high LDL-cholesterol and/or low HDL-cholesterol and/or high triglyceride levels) and diabetes (fasting plasma glucose ≥ 7 mmol/l and/or treatment) were present in 947 (15.7%), 1673 (27.0%), 2268 (36.7%), 2113 (34.2%) and 407 (6.6%) of the participants, respectively, and the prevalence was higher in men than in women. In both genders, the prevalence of obesity, hypertension and diabetes increased with age.

Conclusion

The prevalence of major CVRFs is high in the Lausanne population in particular in men. We anticipate that given its size, the depth of the phenotypic analysis and the availability of dense genome-wide genetic data, the CoLaus Study will be a unique resource to investigate not only the epidemiology of isolated, or aggregated CVRFs like the metabolic syndrome, but can also serve as a discovery set, as well as replication set, to identify novel genes associated with these conditions.