Determinants of exercise peak arterial blood pressure, circulatory power, and exercise cardiac power in a population based sample of Finnish male and female aged 30 to 47 years: the Cardiovascular Risk in Young Finns Study
1 Department of Clinical Physiology, Tampere University Hospital, Tampere, Finland
2 Department of Clinical Chemistry, Fimlab laboratories, Tampere University Hospital, Tampere, Finland
3 Research Centre of Applied and Preventive Cardiovascular Medicine, University of Turku, Turku, Finland
4 The School of Medicine, University of Tampere, Tampere, Finland
5 Department of Paediatrics, Tampere University Hospital, Tampere, Finland
6 Department of Medicine, University of Turku, Turku, Finland
7 Department of Clinical Physiology and Nuclear Medicine, Turku University Hospital, Turku, Finland
8 Fimlab laboratories, P.O. Box 66, Tampere, FI 33101, Finland
BMC Cardiovascular Disorders 2014, 14:35 doi:10.1186/1471-2261-14-35Published: 13 March 2014
Novel parameters derived from peak maximal oxygen uptake (VO2) and exercise arterial blood pressure, such as peak circulatory power (CP) and exercise cardiac power (ECP), can be used in the risk assessment of cardiovascular disease and stroke. However, the determinants of these factors are poorly characterized in the general population.
We assessed peak arterial blood pressure, CP and ECP with standardized cardiopulmonary exercise test (CPET) on 281 female and 257 male participants of the Cardiovascular Risk in Young Finns Study. The subjects were aged 30–47 years. Peak VO2 as well as systolic and diastolic arterial blood pressures were measured to calculate peak mean arterial pressure, CP and ECP. These parameters were assessed for correlation with sex, age, height, weight, waist-to-hip ratio, smoking, physical activity index (PAI), fasting insulin and glucose levels as well as the use of antihypertensive treatment.
Sex, age and weight explained 36% of the variation in peak systolic blood pressure, and these factors in combination with height and the use of antihypertensive treatment explained 13% of the variation in peak diastolic blood pressure. Sex, height, weight, waist-to-hip ratio, PAI and smoking explained 49% − 52% of the variation in peak CP. Sex, age, height, weight, waist-to-hip ratio, PAI, smoking and insulin levels explained 21% − 49% of variation in ECP.
Subject demographics and lifestyle-related factors should be taken into account when exercise blood pressure response, CP and ECP are used to evaluate patients’ cardiac function in CPET.