Table 1

Baseline variables
GOLD class
I II III IV P
N 5 35 41 9
Age 73 (62–77) 70 (63–77) 66 (63–74) 67 (65–71) 0.740
Female (%) 3 (60.0) 22 (62.9) 27 (65.9) 2 (22.2) 0.205
Hypertension 1 (20) 13 (40.6) 15 (37.5) 1 (11.1) 0.309
Diabetes 1 (20) 3 (9.1) 1 (2.3) 0 (0) 0.038
Dyslipidemia 1 (20) 10 (30.3) 5 (12.5) 0 (0) 0.015
BMI 29 (23–29) 26 (23–30) 24 (21–26) 24 (17–29) 0.109
FEV1,% of predicted 84.8 (83–86.8) 57.6 (52.9–69.9) 40.1 (36.4–43.4) 25.8 (24.6–27.5) <0.001
FVC,% of predicted 101 (92.5–109.6) 96.4 (82.8–107.8) 82.6 (71.1–89.1) 52.2 (49–63) <0.001
FEV1/FVC,% 69 (65–74) 51 (44–60) 41 (35–45) 38 (35–41) <0.001
IC,% of predicted 98.9 (95.8–121.8) 97.3 (87.7–109.8) 80.4 (65.3–96.4) 65.7 (56.1–67.2) <0.001
TLC,% of predicted 105.9 (98.3–115.4)) 122.7 (105.3–134.8) 126 (111.8–134.4) 128.6 (115.1–135)) 0.127
Residual volume,% of predicted 102.9 (101.6–139.2) 155.5 (139.4–185.6) 190 (172–215.4) 241.8 (195.2–252.6) <0.001
FRCpleth,% of predicted 106.7 (100.5–113.2) 146 (117–170.7) 167.2 (148–179.5) 185.9 (168.7–198.9) <0.001
TLCO SB,% of predicted 75.1 (66.7–82.7) 52.6 (43.7–67.3) 40.7 (31–49.5) 30.2 (20.8–42.5) <0.001
IC/TLC 0.40 (0.39–0.46) 0.34 (0.30–0.38) 0.27 (0.22–0.33) 0.22 (0.20–0.23) <0.001
Hemoglobin g/L 130 (116–147) 137 (129–150) 140 (135–147) 142 (130–154) 0.641
Hemoglobin mmol/L 8.1 (7.2–9.1) 8.5 (8–9.3) 8.7 (8.4–9.1) 8.8 (8.1–9.5) 0.641
DpO2 ml/min/m2 281 (279–294) 326 (290–413) 295 (251–329) 366 (349–391) 0.007
SATrest 95 (95–96) 96 (94–96) 95 (96–96) 93 (91–95) 0.048
SATmin 93 (89–95) 91 (87–93) 88 (86–91) 84 (80–85) 0.001
∆ SAT 2 (1–6) 4 (3–6) 7 (4–9) 9 (7–10) 0.003
6MWD 520 (450–575) 425 (355–510) 380 (310–450) 355 (325–375) 0.009
TR (mmHg) 27.8 (26.0–28.8) 29.1 (25.8–35.0) 33.2 (28.3–41.0) 40.5 (37.4–48.3) 0.001

FVC = forced volume vital capacity; FEV1 = forced expiratory volume in one second; TLC = total lung capacity; FRCpleth = functional residual capacity; IC = inspiratory capacity; DLCO SB = Single breath diffusing capacity of the lung for carbon monoxide; IC/TLC = inspiratory capacity to total lung capacity ratio; SATrest = Saturation at rest; SATmin = Minimal saturation during 6MWD; ∆ SAT = SATrest - SATmin; 6MWD = 6 minutes walking distance.

Schoos et al.

Schoos et al. BMC Cardiovascular Disorders 2013 13:84   doi:10.1186/1471-2261-13-84

Open Data