Table 1

Demographics of all available, unrelated index cases referred for molecular genetic testing regarding Long QT syndrome in ordinary health care
Mutation positive
Total cohort KCNQ1positive KCNH2positive SCN5Apositive KCNE1positive KCNE2positive RYR2positive LQTS positive Genotype negative
Number of index cases 200 60 25 13 1 1 3 100 97
Mean age, SD range, years 33±20 0-79 36±23 0-79 29±17 3-69 24±16 0-52 49 60 20 13-32 34±21 0-79 32±20 0-76
Sex, female/male 138/62 45/15 19/6 6/7 1/0 1/0 1/2 73/27 65/32
Average QTc, SD range, ms 463±44 305-640 (136) 479±37 403-597 (41) 472±30 436-565 (20) 505±66 434-640 (10) 447-(1) 478-(1) 428 395-454 (3) 481±41 403-640 (73) 445±41 305-510 (60)
Syncope, % Yes/No 61% 72/46 (118) 53% 19/17 (36) 68% 13/6 (19) 4/4 (8) No (1) No (1) 1/1 (2) 55% 36/29 (65) 69% 35/16 (51)
Family history, % Yes/No 43% 49/65 (114) 76% 29/9 (38) 63% 12/7 (19) 3/3 (6) Yes (1) No (1) 1/1 (2) 69% 45/20 (65) 6% 3/44 (47)
Β-blockers, % Yes/No 52% 59/54 (113) 67% 22/11 (33) 68% 13/6 (19) 3/8 (8) Yes (1) Yes (1) 2/0 (2) 65% 40/22 (62) 35% 17/32 (49)

The numbers in parenthesis refers to the number of cases in each category. No percentages are calculated if there are less than 10 cases.

Stattin et al.

Stattin et al. BMC Cardiovascular Disorders 2012 12:95   doi:10.1186/1471-2261-12-95

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