Open Access Research article

Comparison of zotarolimus-eluting and sirolimus-eluting coronary stents: a study from the Western Denmark Heart Registry

Michael Maeng1*, Lisette Okkels Jensen2, Anne Kaltoft1, Hans-Henrik Tilsted3, Evald Høj Christiansen1, Per Thayssen2, Morten Madsen4, Henrik Toft Sørensen45, Jens Flensted Lassen1 and Leif Thuesen1

Author Affiliations

1 Department of Cardiology, Aarhus University Hospital, Skejby, Brendstrupgaardsvej 100, 8200, Aarhus N, Denmark

2 Department of Cardiology, Odense University Hospital, Odense, Denmark

3 Department of Cardiology, Aarhus University Hospital, Aalborg Hospital, Aalborg, Denmark

4 Department of Clinical Epidemiology, Aarhus University Hospital, Aarhus, Denmark

5 Department of Epidemiology, Boston University, Boston, MA, USA

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BMC Cardiovascular Disorders 2012, 12:84  doi:10.1186/1471-2261-12-84

Published: 2 October 2012



We evaluated the effectiveness and safety of a zotarolimus-eluting (ZES) versus a sirolimus-eluting (SES) coronary stent in a large cohort of patients treated with one of these stents in Western Denmark.


A total of 6,122 patients treated with ZES (n=2,282) or SES (n=3,840) were followed for up to 27 months. We ascertained clinical outcomes based on national medical databases.


Incidence of target lesion revascularization (no. per 100 person-years) was 5.3 in the ZES group compared to 1.9 in the SES group (adjusted hazard ratio (HR)=2.19, 95% confidence intervals (CI): 1.39-3.47; p=0.001). All-cause mortality was also higher in the ZES group (ZES: 6.3; SES: 3.3; adjusted HR=1.34, 95% CI: 1.05-1.72; p=0.02), while stent thrombosis (ZES: 1.2; SES: 0.5; adjusted HR=1.98, 95% CI: 0.75-5.23; p=0.14) did not differ significantly.


In agreement with previously published randomised data, this observational study indicated that the ZES was associated with an increased risk of death and TLR in a large cohort of consecutive patients.

Zotarolimus; Sirolimus; Stent; Mortality; Stent thrombosis; Diabetes mellitus