Table 4

Association of new AMI hospitalization and current use of NSAIDs by mean dose of NSAIDs used per day

NSAIDs used (DDDs per day)

Crude OR

95% CI

Adjusted OR*

95% CI


Oral celecoxib

low dose (> 0, < 0.5)

1.11

0.15 -

7.91

1.39

0.18 -

10.70

high dose (≥ 0.5)

1.49

1.05 -

2.11

1.47

1.02 -

2.12

Oral ns-NSAIDs overall

low dose (> 0, < 0.5)

1.22

0.85 -

1.76

1.12

0.76 -

1.65

high dose (≥ 0.5)

1.65

1.42 -

1.93

1.56

1.32 -

1.83

Parenteral ns-NSAIDs overall

low dose (> 0, < 0.5)

3.77

2.73 -

5.19

2.96

2.12 -

4.14

high dose (≥ 0.5)

14.60

3.45 -

61.87

11.79

2.73 -

50.99


95%CI = 95% confidence interval; ns-NSAIDs = non-selective NSAIDs; DDD = defined daily dose

* Conditional logistic regression adjusted for important potential time-varying confounding variables of all discordant use of antihypertensive agents, angiotensin converting enzyme inhibitors or aldosterone receptor blockers, calcium channel blockers, statins, insulin, sulfonylurea, thiazolidinedione, and aspirin between case and control period

Shau et al. BMC Cardiovascular Disorders 2012 12:4   doi:10.1186/1471-2261-12-4

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