Table 3

Adjusted odds ratio and 95% confidence interval for new AMI hospitalization with NSAIDs stratified by hypertension and use of low dose aspirin

Hypertension diagnosis

Low dose aspirin



with

without

p value

for interaction

user

non-user

p value for interaction

(N = 3,672)

(N = 4,682)

(N = 905)

(N = 7,449)

aOR*

95%CI

aOR*

95%CI

aOR*

95%CI

aOR*

95%CI





ns-NSAIDs

Oral overall

1.56

1.36 - 1.79

1.32

1.15 - 1.51

0.05

1.48

1.10 - 1.99

1.42

1.28 - 1.57

0.93

Parenteral overall

3.43

2.30 - 5.13

3.18

2.08 - 4.87

0.95

4.95

1.96 - 12.50

3.24

2.38 - 4.40

0.93

Oral

celecoxib

1.81

1.07 - 3.05

1.10

0.66 - 1.83

0.51

1.66

0.67 - 4.10

1.36

0.91 - 2.02

0.43

diclofenac

1.33

1.11 - 1.60

1.26

1.04 - 1.52

0.50

1.17

0.77 - 1.76

1.30

1.13 - 1.49

0.68

naproxen

1.30

0.81 - 2.10

1.17

0.67 - 2.04

0.83

2.66

0.89 - 7.91

1.15

0.78 - 1.69

0.27

ketorolac

7.64

1.74 - 33.47

0.86

0.36 - 2.09

0.03

1.30

0.21 - 8.02

2.19

1.01 - 4.75

0.57

Parenteral

ketorolac

4.96

2.82 - 8.71

3.71

2.16 - 6.39

0.62

7.47

2.31 - 24.21

4.06

2.69 - 6.13

0.66

ketoprofen

2.73

1.18 - 6.31

1.92

0.83 - 4.46

0.36

1.20

0.09 - 16.21

2.38

1.31 - 4.35

0.39

diclofenac

1.08

0.44 - 2.65

3.84

1.09 - 13.52

0.15

2.28

0.22 - 24.06

1.86

0.90 - 3.83

0.91


aOR = adjusted odds ratio; 95%CI = 95% confidence interval; ns-NSAIDs = non-selective NSAIDs

* Conditional logistic regression adjusted for important potential time-varying confounding variables of all discordant use of antihypertensive agents, angiotensin converting enzyme inhibitors or aldosterone receptor blockers, calcium channel blockers, statins, insulin, sulfonylurea, thiazolidinedione, and aspirin between case and control period

Shau et al. BMC Cardiovascular Disorders 2012 12:4   doi:10.1186/1471-2261-12-4

Open Data