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Open Access Highly Accessed Research article

Novel Toll-like receptor-4 deficiency attenuates trastuzumab (Herceptin) induced cardiac injury in mice

Nasser Ghaly Yousif* and Fadhil G Al-amran

BMC Cardiovascular Disorders 2011, 11:62  doi:10.1186/1471-2261-11-62

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use in the clinical

Joon Anderson   (2011-11-17 13:57)  Research Institute

This is a good study, but we need to confirm this result in the clinical trial, because the cardiomyopathy is a real adverse effect of trastuzumab when we used it in the treatmnet of Her2/neu positive breast cancer.

Competing interests

None declared


intersting study!!

MARIA LUISE   (2011-11-17 13:53)  MD,ANDERSON CANCER CENTER email

This is agood study to explained the mechanism of trastuzumab toxicity.

Competing interests

None declared


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