Table 2 |
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|
Prediction of poor outcome with clinical, electrophysiological and biological variables |
||||
|
Patients tested, n |
Abnormal test result, % (95% CI) |
False positive rate*, % (95% IC) |
Positive likelihood ratio (95% IC) |
|
|
|
||||
|
Motor response ≤ 2 |
||||
|
- 24 h-36 h |
97 |
87% [80% - 93%] |
56% [45%- 67% |
1.7 [1.2 - 2.5] |
|
- 72 h |
87 |
70% [61% - 80%] |
16% [7% - 25%] |
5.8 [2.3 -1 4.1] |
|
No corneal reflexes |
||||
|
- 24 h-36 h |
95 |
40% [30% - 50%] |
12% [2% - 22%] |
4.2 [1.4 - 12.4] |
|
- 72 h |
86 |
36% [26% - 46%] |
0% [0%-14%] |
26 [1.7 - 415] |
|
No pupillary reflexes |
||||
|
- 24 h-36 h |
97 |
26% [17% - 35%] |
4% [4% - 12%] |
8.3 [1.2 - 58] |
|
- 72 h |
87 |
21% [12% - 29%] |
0% [0% - 14%] |
15 [1 - 244] |
|
Myoclonus |
||||
|
- 24 h-36 h |
97 |
27% [18% - 36%] |
0% [0% -14%] |
19 [1.2 - 299] |
|
- 72 h |
87 |
23% [14% - 32%] |
8% [4% - 20%] |
|
|
Epilepsy |
||||
|
- 24 h-36 h |
97 |
7% [7% - 12%] |
0% [0% -14%] |
5.3 [0.3-90] |
|
- 72 h |
87 |
7% [2% - 12%] |
0% [0% -14%] |
5.3 [0.31-91] |
|
- Malignant EEG ** |
||||
|
- 24-36 h |
90 ¶ |
44% [34% - 55%] |
4% [2% - 10%] |
14 [2.1-97] |
|
- 72 h |
73¶¶ |
44% [33% - 55%] |
0% [0% -17%] |
25 [1.6-394] |
|
Highest measurement of NSE ≥ 47 ng/mL |
||||
|
97 |
58% [48% - 68%] |
7% [0,4% - 14%] |
4.5 [1.8 -11] |
|
|
Highest measurement of NSE ≥ 97 ng/mL |
||||
|
97 |
36% [27% - 46%] |
0% [0% -13%] |
25 [1.6-397] |
|
|
|
||||
|
* Patients with abnormal test results and good outcome/all patients with abnormal test results (1-positive predictive value) ** included isoelectric and burst-suppression pattern with interburst interval of at least 1s and generalised continuous epileptiform discharges ¶ Forty-four patients were still affected by sedative medication ¶¶ twenty-one patients were still affected by sedative medication |
||||
|
Daubin et al. BMC Cardiovascular Disorders 2011 11:48 doi:10.1186/1471-2261-11-48 |
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