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Serum neuron-specific enolase as predictor of outcome in comatose cardiac-arrest survivors: a prospective cohort study

Cédric Daubin1*, Charlotte Quentin2, Stéphane Allouche34, Olivier Etard5, Cathy Gaillard6, Amélie Seguin1, Xavier Valette1, Jean-Jacques Parienti67, Fabrice Prevost1, Michel Ramakers1, Nicolas Terzi89, Pierre Charbonneau1 and Damien du Cheyron110

Author Affiliations

1 Department of Medical Intensive Care, CHU de Caen, Caen, F-14000, France

2 Department of Medical Intensive Care, Mémorial France-Etats-Unis Hospital, Saint-Lô, France

3 Department of Biochemistry, CHU de Caen, Caen, F-14000, France

4 UPRES EA 3919, CHU de Caen, Caen University, Caen, F-14000, France

5 Laboratory of Neurological Functional Exploratory, CHU de Caen, Caen, F-14000, France

6 Department of Biostatistics and Clinical Research, CHU de Caen, Caen, F-14000, France

7 INSERM, UMR-S 707, Paris, F-75012, France

8 INSERM, ERI27, Caen, F-14000 France; Univ Caen, Caen, F-14000 France; CHRU Caen, Department of Medical Intensive Care, Caen, F-14000, France

9 E.A. 4497, Université de Versailles-Saint Quentin en Yvelines, 92380 Garches, France

10 UPRES, EA 2128, Caen, F-14000, France

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BMC Cardiovascular Disorders 2011, 11:48  doi:10.1186/1471-2261-11-48

Published: 8 August 2011

Additional files

Additional file 1:

" Receiver operating characteristic curves for 72 h NSE values (ng/mL) to predict poor neurological outcome. This file highlight that considering 72 h-NSE values (n = 61), a level ≥ 68 ng/mL predicted a poor outcome (CPC 4-5) with a positive predictive value of 100% [95% IC = 100% - 100%] and a sensitivity of 67% [95% IC = 54% - 81%].

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