Table 3

Linear regression models predicting Lp-PLA2 activity (nmol/mL-min)

Race & Sex (Model1)

Model1 + Biological Covariates

Model 1 + Lifestyle Covariates

Model1 + SNPs*

All Covariates

Variables

β

P-value

β

P-value

β

P-value

β

P-value

β

P-value


Race

African-American

-24.7

< 0.0001

-18.5

< 0.0001

-27.0

< 0.0001

-22.8

< 0.0001

-18.0

< 0.0001

Hispanic

-10.1

0.009

-10.6

0.0006

-14.4

0.0006

-10.2

0.009

-13.1

0.0001

Asian

-12.1

0.003

-14.2

< 0.0001

-10.4

0.018

-11.9

0.004

-13.9

0.0001

Female gender

-28.1

< 0.0001

-18.2

< 0.0001

-28.3

< 0.0001

-27.6

< 0.0001

-17.4

< 0.0001

Biological Covariates

Age (years)

1.05

0.0006

1.13

0.0006

Diabetes mellitus

-0.057

0.038

-0.067

0.024

History of hypertension

-2.38

0.23

-3.65

0.094

Systolic blood pressure (mmHg)

-0.0034

0.95

0.0012

0.98

Body mass index (kg/m2)

-0.41

0.29

-0.34

0.39

Waist circumference (cm)

0.041

0.79

-0.0066

0.97

LDL (mg/dL)

0.44

< 0.0001

0.45

< 0.0001

HDL (mg/dL)

-0.69

< 0.0001

-0.72

< 0.0001

ADMA§ (μmol/L)

23.4

0.0048

23.1

0.012

C-reactive protein (mg/L)

-0.23

0.10

-0.22

0.13

Lifestyle/Demographic Covariates

Current smoking

0.035

0.43

0.025

0.49

Exercise (kCal/kg-day)

0.36

0.30

0.38

0.17

% Calories from saturated fat

1.09

0.038

0.047

0.91

% Calories from carbohydrates

0.31

0.045

-0.055

0.66

Annual income ≥ $50,000

-0.023

0.38

0.011

0.60

College graduate

-0.0095

0.70

0.014

0.48

SNPs

Ala379Val

1.20

0.55

1.45

0.40

Arg92His

-2.06

0.26

-3.75

0.015

Ile198Thr

-6.03

0.056

-4.38

0.11


* SNPs, single nucleotide polymorphisms

Compared to White race

Compared to Male

§ADMA, asymmetric dimethylarginine

Lee et al. BMC Cardiovascular Disorders 2011 11:38   doi:10.1186/1471-2261-11-38

Open Data