Table 3 |
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|
Linear regression models predicting Lp-PLA2 activity (nmol/mL-min) |
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|
Race & Sex (Model1) |
Model1 + Biological Covariates |
Model 1 + Lifestyle Covariates |
Model1 + SNPs* |
All Covariates |
||||||
|
Variables |
β |
P-value |
β |
P-value |
β |
P-value |
β |
P-value |
β |
P-value |
|
|
||||||||||
|
Race† |
||||||||||
|
African-American |
-24.7 |
< 0.0001 |
-18.5 |
< 0.0001 |
-27.0 |
< 0.0001 |
-22.8 |
< 0.0001 |
-18.0 |
< 0.0001 |
|
Hispanic |
-10.1 |
0.009 |
-10.6 |
0.0006 |
-14.4 |
0.0006 |
-10.2 |
0.009 |
-13.1 |
0.0001 |
|
Asian |
-12.1 |
0.003 |
-14.2 |
< 0.0001 |
-10.4 |
0.018 |
-11.9 |
0.004 |
-13.9 |
0.0001 |
|
Female gender‡ |
-28.1 |
< 0.0001 |
-18.2 |
< 0.0001 |
-28.3 |
< 0.0001 |
-27.6 |
< 0.0001 |
-17.4 |
< 0.0001 |
|
Biological Covariates |
||||||||||
|
Age (years) |
1.05 |
0.0006 |
1.13 |
0.0006 |
||||||
|
Diabetes mellitus |
-0.057 |
0.038 |
-0.067 |
0.024 |
||||||
|
History of hypertension |
-2.38 |
0.23 |
-3.65 |
0.094 |
||||||
|
Systolic blood pressure (mmHg) |
-0.0034 |
0.95 |
0.0012 |
0.98 |
||||||
|
Body mass index (kg/m2) |
-0.41 |
0.29 |
-0.34 |
0.39 |
||||||
|
Waist circumference (cm) |
0.041 |
0.79 |
-0.0066 |
0.97 |
||||||
|
LDL (mg/dL) |
0.44 |
< 0.0001 |
0.45 |
< 0.0001 |
||||||
|
HDL (mg/dL) |
-0.69 |
< 0.0001 |
-0.72 |
< 0.0001 |
||||||
|
ADMA§ (μmol/L) |
23.4 |
0.0048 |
23.1 |
0.012 |
||||||
|
C-reactive protein (mg/L) |
-0.23 |
0.10 |
-0.22 |
0.13 |
||||||
|
Lifestyle/Demographic Covariates |
||||||||||
|
Current smoking |
0.035 |
0.43 |
0.025 |
0.49 |
||||||
|
Exercise (kCal/kg-day) |
0.36 |
0.30 |
0.38 |
0.17 |
||||||
|
% Calories from saturated fat |
1.09 |
0.038 |
0.047 |
0.91 |
||||||
|
% Calories from carbohydrates |
0.31 |
0.045 |
-0.055 |
0.66 |
||||||
|
Annual income ≥ $50,000 |
-0.023 |
0.38 |
0.011 |
0.60 |
||||||
|
College graduate |
-0.0095 |
0.70 |
0.014 |
0.48 |
||||||
|
SNPs |
||||||||||
|
Ala379Val |
1.20 |
0.55 |
1.45 |
0.40 |
||||||
|
Arg92His |
-2.06 |
0.26 |
-3.75 |
0.015 |
||||||
|
Ile198Thr |
-6.03 |
0.056 |
-4.38 |
0.11 |
||||||
|
|
||||||||||
|
* SNPs, single nucleotide polymorphisms † Compared to White race ‡ Compared to Male §ADMA, asymmetric dimethylarginine |
||||||||||
|
Lee et al. BMC Cardiovascular Disorders 2011 11:38 doi:10.1186/1471-2261-11-38 |
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