Table 5

Non-parametric comparisons of cardiac parameters after 2 weeks of exposure to isoproterenol and treatment with P188 in BL10 and mdx mice.

Measurement

Group

N

Median

Range

Overall p-value

Significantly different groups


Heart rate (bpm)

BL10 - Untx

3

451

410 - 466


BL10 - Iso

7

645

593 - 691

BL10-Iso vs. MDX-Untx (p = 0.0267)


MDX - Untx

6

454

416 - 477

0.0001

MDX-Untx vs. MDX-Iso (p = 0.0325)


MDX - Iso

10

593

462 - 632

MDX-Untx vs. MDX-Iso+P188 (p = 0.0129)


MDX - Iso + P188

9

667

632 - 686

MDX-Iso vs. MDX-Iso+P188 (p = 0.0008)


EF%

BL10 - Untx

3

60.35

59.17 - 61.32


BL10 - Iso

7

80.03

77.40 - 86.59

BL10-Iso vs. MDX-Untx (p = 0.0267)


MDX - Untx

6

59.00

50.93 - 62.22

0.0001

BL10-Iso vs. MDX-Iso (p = 0.0060)


MDX - Iso

10

65.00

50.15 - 75.10

MDX-Untx vs. MDX-Iso+P188 (p = 0.0149)


MDX - Iso + P188

9

74.85

69.98 - 81.18


Diastolic BP (mmHg)

BL10 - Untx

3

74

57 - 86


BL10 - Iso

7

95

83 - 102


MDX - Untx

3

58

39 - 62

0.0026

BL10-Iso vs. MDX-Iso (p = 0.0441)

BL10-Iso vs. MDX-Iso+P188 (p = 0.0267)


MDX - Iso

5

56

50 - 66


MDX - Iso + P188

6

53

44 - 60


Mean BP (mmHg)

BL10 - Untx

3

78

67 - 89


BL10 - Iso

7

97

89 - 106


MDX - Untx

3

67

56 - 71

0.0031

BL10-Iso vs. MDX-Iso (p = 0.0431)

BL10-Iso vs. MDX-Iso+P188 (p = 0.0267)


MDX - Iso

5

63

59 - 73


MDX - Iso + P188

6

66

57 - 71


Bpm - beats per minute; EF% - ejection fraction percent; BP - blood pressure; mmHg - millimeters of mercury; SD - standard deviation; iso - isoproterenol; untx - untreated

Spurney et al. BMC Cardiovascular Disorders 2011 11:20   doi:10.1186/1471-2261-11-20

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