Figure 8.

Blockade of sarcoplasmic reticulum Ca⁺⁺ channel, by prior incubation with 5 × 10^-5 M ryanodine (n = 10 rings per group), does not alter sevoflurane mediated vasodilation. Sevoflurane produced significant dose dependent vasodilation compared to control conditions, which was not modulated by ryanodine. *P < 0.05 compared to rings exposed to control conditions. (Two way RM-ANOVA).