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Gas exchange, respiratory and arteriovenous extracorporeal lung assist parameters, before and after lung injury, post recruitment and during the time course |
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| TBaseline |
TARDS |
TRM |
3 Hz/ECLA |
3 Hz |
6 Hz/ECLA |
6 Hz |
|
|
|
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| RR |
30+/-0 |
30+/-0 |
180+/-0§ |
180+/-0§ |
180+/-0§ |
360+/-0§ |
360+/-0§ |
| mPaw |
9.3+/-0.4§ |
13.2+/-1.4 |
22.6+/-1.1§ |
22.6+/-1.1§ |
22.6+/-1.1§ |
22.6+/-1.1§ |
22.6+/-1.1§ |
| FiO2 |
1.0+/-0 |
1.0+/-0 |
1.0+/-0 |
1.0+/-0 |
1.0+/-0 |
1.0+/-0 |
1.0+/-0 |
| pHa |
7.45+/-0.09 |
7.41+/-0.06 |
7.55+/-0.04§ |
7.6+/-0.04§ |
7.58+/-0.07§ |
7.48+/-0.07 |
7.4+/-0.08* |
| PaO2 |
585+/-24§ |
60+/-12 |
532+/-116§ |
563+/-69§ |
551+/-75§ |
549+/-68§ |
556+/-60§ |
| PaCO2 |
37.7+/-4.2 |
42.7+/-5.3 |
27.7+/-3.5§ |
27.1+/-6§ |
26.3+/-5.3§ |
34+/-4.6 |
44.6+/-12.5* |
| SvO2 |
86.1+/-4.1§ |
67.9+/-6.1 |
85.5+/-2.7§ |
89.1+/-3.2§ |
82.4+/-6.3§ |
86.8+/-3.7§ |
76.8+/-6.7§* |
| DO2 |
906+/-295 |
739+/-251 |
919+/-223 |
920+/-198 |
706+/-189* |
804+/-192 |
593+/-211* |
| VO2 |
197+/-35 |
169+/-30 |
214+/-34§ |
192+/-31 |
184+/-31 |
182+/-39 |
182+/-38 |
| Qs/Qt |
0.07+/-0.02§ |
0.54+/-0.09 |
0.12+/-0.09§ |
0.11+/-0.07§ |
0.1+/-0.06§ |
0.11+/-0.06§ |
0.07+/-0.04§* |
| Plow |
5.8+/-0.5§ |
19.6+/-1.1 |
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| PECLAO2 |
564+/-36 |
574+/-45 |
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| SGF |
0+/-0 |
2.4+/-2.3 |
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| EBF |
1.4+/-0.2 |
1.4+/-0.2 |
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| EBF/CO |
21+/-6 |
25+/-6 |
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|
|
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| 9 Hz/ECLA |
9 Hz |
12 Hz/ECLA |
12 Hz |
15 Hz/ECLA |
15 Hz |
End |
|
|
|
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| RR |
540+/-0§ |
540+/-0§ |
720+/-0§ |
720+/-0§ |
900+/-0§ |
900+/-0§ |
180+/-0§ |
| mPaw |
22.6+/-1.1§ |
22.6+/-1.1§ |
22.6+/-1.1§ |
22.6+/-1.1§ |
22.6+/-1.1§ |
22.6+/-1.1§ |
22.6+/-1.1§ |
| FiO2 |
1.0+/-0 |
1.0+/-0 |
1.0+/-0 |
1.0+/-0 |
1.0+/-0 |
1.0+/-0 |
1.0+/-0 |
| pHa |
7.46+/-0.05 |
7.34+/-0.08* |
7.45+/-0.05 |
7.29+/-0.08* |
7.43+/-0.06 |
7.26+/-0.07* |
7.54+/-0.05§ |
| PaO2 |
554+/-74§ |
553+/-56§ |
557+/-71§ |
542+/-59§ |
550+/-53§ |
508+/-70§S* |
579+/-25§ |
| PaCO2 |
37.5+/-4 |
53.2+/-13.3§* |
39+/-4.2 |
61.1+/-13.7§* |
39.9+/-5.5 |
66.8+/-12.7§* |
29.5+/-3.6§ |
| SvO2 |
86.5+/-3.1§ |
74.2+/-5.5§* |
86.1+/-3.2§ |
75.5+/-4§* |
85.3+/-4§ |
75.7+/-7§* |
80.7+/-4.5§ |
| DO2 |
764+/-152 |
538+/-118* |
767+/-110 |
558+/-135* |
819+/-194 |
590+/-169* |
616+/-76 |
| VO2 |
177+/-38 |
181+/-32 |
180+/-34 |
181+/-36 |
194+/-33 |
182+/-29 |
178+/-38 |
| Qs/Qt |
0.1+/-0.07§ |
0.06+/-0.03§* |
0.1+/-0.07§ |
0.06+/-0.04§* |
0.1+/-0.05§ |
0.08+/-0.04§ |
0.08+/-0.03§ |
| Plow |
20.7+/-3.5 |
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| PECLAO2 |
608+/-36 |
628+/-22 |
620+/-28 |
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| SGF |
3.9+/-4.1 |
5+/-4 |
5+/-4.1 |
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| EBF |
1.5+/-0.2 |
1.4+/-0.2 |
1.4+/-0.3 |
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| EBF/CO |
27+/-6 |
26+/-2 |
24+/-4 |
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Data expressed as means ± standard deviation; ECLA, arteriovenous extracorporeal lung assist; ARDS, acute respiratory distress syndrome; PRM, post recruitment; RR, respiratory rate per minute; mPaw, mean pulmonary airway pressure in cmH2O; FiO2, fraction of inspired oxygen; PaO2, arterial oxygen partial pressure in mmHg; PaCO2, arterial carbon dioxide partial pressure in mmHg; SvO2, mixed venous oxygen saturation; DO2, oxygen; delivery in l/min/m2; VO2, oxygen consumption in l/min/m2;Qs/Qt, pulmonary shunt fraction; Plow, lower inflection point in cmH2O;PECLAO2, partial oxygen pressure behind lung assist in mmHg; SGF, Sweep Gas Flow in l/min; EBF, ECLA Blood Flow in l/min; CO, cardiac output; * p < 0.05 ECLA vs. No ECLA; §p < 0.05 vs. TARDS. | |||||||
Muellenbach et al. BMC Anesthesiology 2008 8:7 doi:10.1186/1471-2253-8-7 |
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