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Included, randomized, double-blind, controlled studies of gabapentin in postoperative pain. |
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| Reference |
Quality Score |
Surgical procedure |
η gabapentin/placebo |
Gabapentin dosing & administration |
Analgesic and delivery |
Effect on analgesic consumption (24 hours) |
Effect on pain score at rest (6 h) |
Effect on pain score at rest (24 h) |
Side-effects |
|
|
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| Dierking 2004 [27] |
5 |
Abdominal hysterectomy |
39/32 |
1200 mg 1 h pre-op. + 600 mg × 3 |
PCA – morphine |
Morphine reduced from 63 to 43 mg |
NS |
NS |
NS |
| Turan 2004a [28] |
5 |
Abdominal hysterectomy |
25/25 |
1200 mg 1 h pre-op. |
PCA – tramadol intravenously |
Tramadol reduced from 420 to 270 mg |
VAS lower with gabapentin (P = 0.000) |
VAS lower with gabapentin (P = 0.000) |
NS |
| Gilron 2004 [30] |
5 |
Abdominal hysterectomy |
23/24 |
600 mg 1 h pre-op. + 600 mg × 2 |
PCA -morphine |
Morphine reduced from 82 to 57 mg |
VAS lower with gabapentin (P < 0.001) |
VAS lower with gabapentin (P < 0.02) |
Sedation increased with gabapentin |
| Turan 2006a [29] |
5 |
Abdominal hysterectomy |
25/25 |
1200 mg 1 h pre-op. |
PCA -morphine |
Morphine reduced from 53 to 41 mg |
VAS lower with gabapentin (P < 0.01) |
VAS lower with gabapentin (P < 0.05) |
NS |
| Fassoulaki 2006 [31] |
3 |
Abdominal hysterectomy |
25/28 |
400 mg × 4 initiated day before surgery |
PCA – morphine |
Morphine reduced from 26 to 20 mg |
NS |
NS |
|
| Pandey 2004a [32] |
4 |
Lumbar discoidectomy |
28/28 |
300 mg 2 h pre-op. |
Fentanyl on demand |
Fentanyl reduced from 360 to 234 ug |
VAS lower with gabapentin (P < 0.05) |
VAS lower with gabapentin (P < 0.05) |
NS |
| Pandey 2005a [24] |
5 |
Lumbar discoidectomy |
4 × 20/20 |
300–600–900–1200 mg 2 h pre-op. (4 diff. groups) |
PCA-fentanyl |
Fentanyl reduced from 1218 to 627–988 ug |
VAS lower with gabapentin (P < 0.05) |
VAS lower with gabapentin (P < 0.05) |
NS |
| Turan 2004b [33] |
5 |
Lumbar discoidectomy or spinal fusion |
25/25 |
1200 mg 1 h pre-op. |
PCA-morphine |
Morphine reduced from 43 to 16 mg |
VAS lower with gabapentin. (P < 0.01) |
NS |
Vomiting reduced with gabapentin |
| Radhakrishnan 2005 [34] |
4 |
Lumbar discoidectomy/laminectomy |
30/30 |
400 mg night before surgery + 400 mg 2 h pre-op. |
PCA-morphine (study lasted for 8 h) |
NS (study lasted for 8 h) |
NS |
NS |
|
| Dirks 2002 [35] |
5 |
Radical mastectomy |
31/34 |
1200 mg 1 h preop. |
PCA-morphine (study lasted for 4 h) |
Morphine reduced from 29 to 15 mg |
VAS lower with gabapentin (P < 0.018) |
NS |
|
| Fassoulaki 2002 [36] |
4 |
Matectomy or lumpectomy with axillary dissection |
22/24 |
400 mg × 3 starting the evening before surgery |
On demand. (Propoxyphene & paracetamol given i.m.) |
NS |
NS |
NS |
NS |
| Pandey 2005b [26] |
5 |
Nefrectomy |
2 × 20/20 |
Pre-incision (2 h pre-op.)/post-incision groups. 600 mg in both. |
PCA-fentanyl |
Fentanyl reduced from 925 to 563 ug/624 ug |
VAS lower with gabapentin in both groups (P < 0.05) |
VAS lower with gabapentin in both groups (P < 0.05) |
NS |
| Bartholdy 2006 [38] |
5 |
Laparascopic sterilization |
38/38 |
1200 mg 1/2 h pre-op. |
PCA-morphine (Study lasted for 4 h) |
NS |
NS |
NS |
NS |
| Pandey 2004b [37] |
3 |
Laparascopic chole-cystectomy |
153/153 |
300 mg 2 h pre-op. |
Fentanyl on demand. |
Fentanyl reduced from 356 to 221 ug |
VAS lower with gabapentin (P < 0.05) |
VAS lower with gabapentin (P < 0.05) |
Sedation + PONV increased with gabapentin |
| Omran 2005 [39] |
5 |
Pulmonal lobectomy |
25/25 |
1200 mg 1 h pre-op. and 600 mg × 2 |
PCA-morphine |
Morphine reduced from 32 to 24 mg |
VAS lower with gabapentin (P < 0.05) |
VAS lower with gabapentin (P < 0.05) |
NS, vomiting reduced with gabapentin |
| Tuncer 2005 [25] |
1 |
Major orthopedic surgery |
2 × 15/15 |
1200 – 800 mg 1 h pre-op. |
PCA-morphine (Study lasted only 4 hours) |
Morphine reduced from 21 to 11 mg/15 mg |
NS |
NS |
|
| Menigaux 2005 [40] |
5 |
Arthroscopic anterior cruciate ligament repair |
20/20 |
1200 mg 1–2 h preop. |
PCA-morphine |
Morphine reduced from 48 to 21 mg |
NS |
NS |
NS |
| Adam 2006 [41] |
5 |
Arthropscopic shoulder surgery |
27/26 |
800 mg 2 h pre-op. |
Nerveblock + on demand paracetamol + propoxyphene |
NS |
NS |
NS |
NS |
| Turan 2007 [42] |
5 |
Hand surgery |
20/20 |
1200 mg 1 h pre-op. |
IVRA + diclofenac according to VAS score |
Diclofenac reduced from 63 to 30 mg |
NS |
NS |
NS |
| Turan 2006b [43] |
5 |
Lower extremity plastic surgery |
20/20 |
1200 mg 1 h pre-op. |
PCEA bolus (bupivacaine and fentanyl) |
PCEA bolus reduced with gabapentin |
VAS lower with gabapentin (P < 0.001) |
NS |
NS, dizziness increased with gabapentin |
| Al-Mujadi 2006 [45] |
5 |
Thyroid surgery |
37/35 |
1200 mg 2 h pre-op. |
Morphine according to VAS score |
Morphine reduced from 30 to 15 mg |
VAS lower with gabapentin (P < 0.01) |
VAS lower with gabapentin (P < 0.01) |
NS |
| Mikkelsen 2006 [46] |
5 |
Tonsillectomy |
22/27 |
1200 mg 1 h pre-op. + 600 mg × 2 |
Morphine on demand + tbl. Ketobemidone by patient |
Morphine NS. Ketobemidone reduced from 4.5 to 2.0 mg |
NS |
NS |
Dizziness & vomiting increased with gabapentin |
| Turan 2004c [44] |
5 |
Ear-Nose-Throat surgery |
25/25 |
1200 mg 1 h pre-op. |
Diclofenac according to VAS |
Diclofenac reduced from 111 to 33 mg |
VAS lower with gabapentin (P < = .001) |
VAS lower with gabapentin (P < 0.001) |
NS, dizziness increased with gabapentin |
|
PCA, patient-controlled analgesia; NS, not significant; pre-op, pre-operatively; VAS, visual analogue scale; IVRA, intravenous regional anaesthesia; PCEA, patient-controlled epidural analgesia; | |||||||||
Mathiesen et al. BMC Anesthesiology 2007 7:6 doi:10.1186/1471-2253-7-6 |
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