Table 4

Adverse effects in dental pain


Adverse effects with active
 Adverse effects with placebo





Number of trials
 Drug and dose
 Number
 Percent
 Number
 Percent
 Relative risk (95% CI)
 NNH/NNTp (95% CI)
Any adverse event
13
 Rofecoxib 50 mg
 459/1330
 35
 231/570
 41
 0.9 (0.8 to 1.0)
 nc
6
 Ibuprofen 400 mg
 102/303
 34
 122/298
 41
 0.8 (0.7 to 1.0)
 nc
1
 Diclofenac 50 mg*
 72/121
 60
 31/63
 41
 1.2 (0.9 to 1.6)
 nc
6
 Ibuprofen 400 mg
 102/303
 34
 122/298
 41
 0.8 (0.7 to 1.0)
 nc
2
 Naproxen 550 mg
 27/88
 31
 25/87
 29
 1.1 (0.7 to 1.7)
 nc
2
 Oxycodone 5 mg + paracetamol 325 mg
 116/180
 64
 29/61
 48
 1.4 (1.02 to 1.8)
 5.9 (3.2 to 39)
2
 paracetamol 600 mg + codeine 60 mg
 146/360
 41
 24/61
 39
 1.0 (0.7 to 1.4)
 nc
Post-extraction alveolitis
13
 Rofecoxib 50 mg
 179/1330
 13
 52/570
 9
 1.5 (1.1 to 2.1)
 24 (14 to 80)
6
 Ibuprofen 400 mg
 23/304
 8
 31/298
 10
 0.7 (0.4 to 1.2)
 nc
1
 Diclofenac 50 mg*
 9/180
 5
 3/63
 5
 1.0 (0.3 to 3.8)
 nc
6
 Ibuprofen 400 mg
 23/304
 8
 31/298
 10
 0.7 (0.4 to 1.2)
 nc
2
 Naproxen 550 mg
 13/88
 15
 8/87
 10
 1.6 (0.7 to 3.4)
 nc
2
 Oxycodone 5 mg + paracetamol 325 mg
 20/180
 11
 7/61
 11
 0.9 (0.4 to 2.2)
 nc
2
 Paracetamol 600 mg + codeine 60 mg
 27/360
 8
 3/61
 6
 1.3 (0.5 to 3.9)
 nc
Dizziness
13
 Rofecoxib 50 mg
 30/1330
 2
 25/570
 5
 0.5 (0.3 to 0.9)
 43 (24 to 253)
6
 Ibuprofen 400 mg
 7/304
 3
 13/298
 5
 0.6 (0.3 to 1.4)
 nc
1
 Diclofenac 50 mg*
 9/180
 8
 5/63
 8
 0.6 (0.2 to 1.8)
 nc
6
 Ibuprofen 400 mg
 7/304
 3
 13/298
 5
 0.6 (0.3 to 1.4)
 nc
2
 Naproxen 550 mg
 1/88
 2
 1/87
 1
 0.9 (0.2 to 9.3)
 nc
2
 Oxycodone 5 mg + paracetamol 325 mg
 44/180
 24
 6/61
 10
 2.5 (1.1 to 5.6)
 6.9 (4.1 to 21)
2
 Paracetamol 600 mg + codeine 60 mg
 19/360
 1
 1/61
 2
 3.3 (0.5 to 24)
 nc
Drowsiness
13
 Rofecoxib 50 mg
 8/1330
 0.6
 1/570
 0.6
 0.9 (0.3 to 3.1)
 nc
6
 Ibuprofen 400 mg
 1/304
 0.7
 0/298
 0.5
 1.3 (0.2 to 11)
 nc
1
 Diclofenac 50 mg*
 5/180
 3
 0/63
 0
 3.5 (0.2 to 64)
 nc
6
 Ibuprofen 400 mg
 1/304
 0.7
 0/298
 0.5
 1.3 (0.2 to 11)
 nc
2
 Naproxen 550 mg
 0/88
 0
 0/87
 0
 0.9 (0.0 to 16)
 nc
2
 Oxycodone 5 mg + paracetamol 325 mg
 6/180
 4
 1/61
 2
 2.2 (0.3 to 18)
 nc
2
 Paracetamol 600 mg + codeine 60 mg
 7/360
 2
 1/61
 2
 1.2 (0.2 to 9.2)
 nc
Nausea
13
 Rofecoxib 50 mg
 112/1330
 8
 80/570
 14
 0.6 (0.5 to 0.8)
 18 (11 to 41)
6
 Ibuprofen 400 mg
 38/304
 12
 51/298
 17
 0.7 (0.5 to 1.08)
 nc
1
 Diclofenac 50 mg*
 21/180
 12
 10/63
 16
 0.7 (0.4 to 1.5)
 nc
6
 Ibuprofen 400 mg
 38/304
 12
 51/298
 17
 0.7 (0.5 to 1.08)
 nc
2
 Naproxen 550 mg
 4/88
 5
 3/87
 3
 1.3 (0.3 to 5.7)
 nc
2
 Oxycodone 5 mg + paracetamol 325 mg
 61/180
 34
 10/61
 17
 2.0 (1.1 to 3.5)
 6.0 (3.5 to 19)
2
 Paracetamol 600 mg + codeine 60 mg
 70/360
 19
 6/61
 10
 2.0 (0.9 to 4.4)
 10 (5.5 to 92)
Vomiting
13
 Rofecoxib 50 mg
 51/1330
 4
 51/570
 9
 0.4 (0.3 to 0.6)
 19 (13 to 38)
6
 Ibuprofen 400 mg
 25/304
 8
 36/298
 12
 0.7 (0.4 to 1.1)
 nc
1
 Diclofenac 50 mg*
 6/180
 3
 7/63
 11
 0.3 (0.1 to 1.0)
 nc
2
 Naproxen 550 mg
 1/88
 2
 1/87
 2
 0.9 (0.1 to 9.3)
 nc
2
 Oxycodone 5 mg + paracetamol 325 mg
 35/180
 19
 3/61
 6
 3.4 (1.2 to 9.8)
 7.2 (4.6 to 18)
2
 Paracetamol 600 mg + codeine 60 mg
 58/360
 16
 4/61
 7
 2.46 (0.9 to 6.5)
 10 (5.9 to 44)

*NB: Diclofenac was taken every eight hours during the study. Naproxen was given as the sodium salt Bold type: NNTp to prevent one event (significantly fewer events occurred with rofecoxib 50 mg compared with placebo

Edwards et al. BMC Anesthesiology 2004 4:3   doi:10.1186/1471-2253-4-3