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Open Access Research article

Concentration-dependent effects of narciclasine on cell cycle progression in Arabidopsis root tips

Xiaofan Na, Yanfeng Hu, Kun Yue, Hongxia Lu, Pengfei Jia, Huahua Wang, Xiaomin Wang and Yurong Bi*

Author Affiliations

School of Life Sciences, Lanzhou University, Lanzhou 730000, People's Republic of China

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BMC Plant Biology 2011, 11:184  doi:10.1186/1471-2229-11-184

Published: 28 December 2011

Abstract

Background

Narciclasine (NCS) is an Amaryllidaceae alkaloid isolated from Narcissus tazetta bulbs. NCS has inhibitory effects on a broad range of biological activities and thus has various potential practical applications. Here we examine how NCS represses plant root growth.

Results

Results showed that the inhibition of NCS on cell division in Arabidopsis root tips and its effects on cell differentiation are concentration-dependent; at low concentrations (0.5 and 1.0 μM) NCS preferentially targets mitotic cell cycle specific/cyclin complexes, whereas at high concentration (5.0 μM) the NCS-stimulated accumulation of Kip-related proteins (KRP1 and RP2) affects the CDK complexes with a role at both G1/S and G2/M phases.

Conclusions

Our findings suggest that NCS modulates the coordination between cell division and differentiation in Arabidopsis root tips and hence affects the postembryonic development of Arabidopsis seedlings.