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Open Access Research article

The leader intron of AtMHX can elicit, in the absence of splicing, low-level intron-mediated enhancement that depends on the internal intron sequence

Tsofit Akua, Irina Berezin and Orit Shaul*

BMC Plant Biology 2010, 10:93  doi:10.1186/1471-2229-10-93

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Introns could also affect mRNA stability

Deng-Ke Niu   (2010-08-09 15:00)  Beijing Normal University email

In this paper, the authors said "Introns stimulate gene expression in a wide range of organisms by increasing the levels of mature mRNA, without affecting mRNA stability". Surely, early studies did not observe significant effect of introns on mRNA stability. Those studies were based on a small number of genes. Later genome-wide analyses have shown that the mRNAs of intron-containing genes are more stable than those of intronless genes (1,2). In addition, there is also a experimental study showing that introducing an intron to a gene could enhance its mRNA stability (3).

1. Wang HF, Feng L and Niu DK (2007). Relationship between mRNA stability and intron presence. Biochemical and Biophysical Research Communications 354: 203-208.

2. Narsai R, Howell KA, Millar AH, O'Toole N, Small I and Whelan J (2007). Genome-wide analysis of mRNA decay rates and their determinants in Arabidopsis thaliana. The Plant Cell 19, 3418-3436.

3. Zhao C and Hamilton T (2007). Introns regulate the rate of unstable mRNA decay. Journal of Biological Chemistry 282, 20230-20237.

Competing interests

No competing interests.

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