Table 1

Statistical significance analysis

2 days
 7 days
 14 days
2 days
 7 days
 14 days

NGF


NT-3

Amitryptiline
 < 0.0001
 n.s.
 n.s.
 Amitryptiline
 < 0.0001
 n.s.
 0.0001
Fluoxetine
 < 0.0001
 n.s.
 n.s.
 Fluoxetine
 < 0.0001
 n.s.
 0.0017
Tranylcypromine
 0.0014
 n.s.
 0.0032
 Tranylcypromine
 < 0.0001
 n.s.
 0.0002
Reboxetine
 < 0.0001
 n.s.
 n.s.
 Reboxetine
 0.0004
 0.0027
 0.0001









bFGF


Leptin

Amitryptiline
 0.0012
 n.s.
 < 0.0001
 Amitryptiline
 < 0.0001
 < 0.0001
 0.0003
Fluoxetine
 < 0.0001
 n.s.
 < 0.0001
 Fluoxetine
 n.s.
 < 0.0001
 < 0.0001
Tranylcypromine
 0.004
 < 0.0001
 n.s.
 Tranylcypromine
 n.s.
 < 0.0001
 < 0.0001
Reboxetine
 < 0.0001
 n.s.
 < 0.0001
 Reboxetine
 n.s.
 0.0021
 < 0.0001









CNTF


CREB

Amitryptiline
 n.s.
 0.0003
 < 0.0001
 Amitryptiline
 n.s.
 < 0.0001
 n.s.
Fluoxetine
 0.001
 < 0.0001
 < 0.0001
 Fluoxetine
 n.s.
 n.s.
 n.s.
Tranylcypromine
 0.002
 < 0.0001
 < 0.0001
 Tranylcypromine
 0.0001
 < 0.0001
 n.s.
Reboxetine
 n.s.
 < 0.0001
 < 0.0001
 Reboxetine
 < 0.0001
 < 0.0001
 0.0002









GDNF

--
 BDNF

Amitryptiline
 0.001
 < 0.0001
 0.005
 Amitryptiline
 n.s.
 n.s.
 0.002
Fluoxetine
 < 0.0001
 < 0.0001
 0.0003
 Fluoxetine
 0.0005
 0.0012
 n.s.
Tranylcypromine
 < 0.0001
 n.s.
 0.0009
 Tranylcypromine
 n.s.
 0.0007
 n.s.
Reboxetine
 n.s.
 n.s.
 0.0006
 Reboxetine
 < 0.0001
 n.s.
 0.0017

Expressions of growth factors were tested with Student's t-test against the corresponding expression levels at the start of the experiments. Expression levels of controls, which were treated for 10 days with PMA, were normalized before testing. The values in the table represent the p-values, obtained by the t-test. The significance level was set at α = 0.004.

Henkel et al. BMC Pharmacology 2008 8:6   doi:10.1186/1471-2210-8-6