Table 1

Top-20 drugs with highest betweenness centrality in the drug network projection corresponding to level 2 of the ATC hierarchical classification. The associated therapy classes as well as closeness centrality, node degree and number of targets are also displayed.

Accession Id

Generic name

Therapy classes

B_i centrality

C_i centrality

Degree

Number of targets

APRD00616

Scopolamine

A04, N05, S01

0.0841

0.469

155

1

APRD00215

Morphine

G04, N02, N04, R05, S01

0.0549

0.479

164

1

APRD00362

Tretinoin

D10, L01

0.0420

0.365

80

3

APRD01080

Magnesium Sulfate

A06, A12, B05, D11, V04

0.0412

0.361

24

3

APRD00373

Celecoxib

L01, M01

0.0340

0.356

94

1

APRD00047

R-mephobarbital

N03, N05

0.0294

0.336

81

1

APRD00406

Physostigmine

S01, V03

0.0261

0.454

106

1

APRD00807

Atropine

A03, N04, S01

0.0251

0.460

126

5

APRD00479

Lidocaine

C01, C05, D04, N01, R02, S01, S02

0.0229

0.470

166

2

APRD00450

Epinephrine

A01, B02, C01, R01, R03, S01

0.0216

0.472

158

3

APRD00097

Orphenadrine

M03, N04

0.0213

0.334

38

5

APRD00267

Tolbutamide

A10, V04

0.0190

0.269

27

2

APRD01022

Hydroxocobalamin

B03, V03

0.0190

0.325

16

8

APRD00013

Neomycin

A01, A07, B05, D06, J01, R02, S01, S02, S03

0.0189

0.488

187

2

APRD00056

Heparin

B01, C05, S01

0.0188

0.454

121

3

APRD00174

Clonidine

C02, N02, S01

0.0185

0.461

136

1

APRD00326

Vitamin B12

A11, B03

0.0167

0.248

12

7

APRD00536

Vitamin B3

C04, C10

0.0167

0.269

21

8

APRD00650

Procaine

C05, D04, J01, N01, S01

0.0164

0.478

199

5

APRD00862

Chloramphenicol

D06, D10, G01, J01, S01, S02, S03

0.0157

0.496

184

1

Nacher and Schwartz BMC Pharmacology 2008 8:5   doi:10.1186/1471-2210-8-5