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Effect of CsA and sulphated polysaccharides on the levels of LPO, 8-OHdG and protein carbonyls |
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| Parameters |
Group I (Control) |
Group II (CsA) |
Group III (Sulphated polysaccharides) |
Group IV (CsA + sulphated polysaccharides) |
|
|
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| LPO |
1.42 ± 0.14 |
3.89 ± 0.43 a*** |
1.38 ± 0.17 |
1.75 ± 0.17 a*b*** |
| 8-OHdG |
11.59 ± 1.04 |
21.25 ± 3.24 a*** |
11.48 ± 1.26 |
15.76 ± 2.25 a**b*** |
| Protein carbonyls |
1.76 ± 0.16 |
3.38 ± 0.41 a*** |
1.73 ± 0.19 |
2.12 ± 0.26 a*b*** |
|
Values are expressed as mean ± S.D. for six animals in each group. Units: LPO: nmoles of MDA formed/min/mg protein; 8-OHdG: fmoles of 8-OHdG/μg of nuclear DNA; Protein carbonyls: μg/mg protein. Comparisons are made between: a-Group I and Groups II, III, IV; b-Group II and Group IV. The symbols (***), (**) and (*) represent statistical significance at P < 0.001, P < 0.01 and P < 0.05, respectively. | ||||
Josephine et al. BMC Pharmacology 2008 8:4 doi:10.1186/1471-2210-8-4 |
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