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Effect of CsA and sulphated polysaccharides on the antioxidant defense system in the hepatic tissues |
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| Antioxidants |
Group I (Control) |
Group II (CsA) |
Group III (Sulphated polysaccharides) |
Group IV (CsA + sulphated polysaccharides) |
|
|
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| Enzymic antioxidants |
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| SOD |
8.73 ± 0.96 |
6.52 ± 0.79 a*** |
8.75 ± 0.87 |
8.54 ± 0.94 b*** |
| CAT |
342.67 ± 41.40 |
260.50 ± 28.63 a*** |
341.92 ± 41.31 |
329.84 ± 32.65 b** |
| GPx |
18.76 ± 1.86 |
12.38 ± 1.63 a*** |
19.01 ± 2.09 |
18.12 ± 1.79b*** |
| Non-enzymic antioxidants |
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| GSH |
16.89 ± 1.86 |
12.53 ± 1.24 a*** |
16.82 ± 2.00 |
16.47 ± 1.81 b*** |
| Vitamin C |
1.92 ± 0.21 |
1.26 ± 0.15 a*** |
1.96 ± 0.19 |
1.67 ± 0.20 a*b** |
| Vitamin E |
0.84 ± 0.08 |
0.56 ± 0.07 a*** |
0.89 ± 0.09 |
0.79 ± 0.08 b*** |
|
Values are expressed as mean ± S.D. for six animals in each group. Units of enzyme activity: SOD: Units/mg protein, one unit is equal to the amount of enzyme that inhibits the auto-oxidation reaction by 50%; CAT: μmoles of H2O2 consumed/min/mg protein; GPx: μg of reduced GSH consumed/min/mg protein; GSH, vitamin C and vitamin E: μg/mg protein. Comparisons are made between: a-Group I and Groups II, III, IV; b-Group II and Group IV. The symbols (***), (**) and (*) represent statistical significance at P < 0.001, P < 0.01 and P < 0.05, respectively. | ||||
Josephine et al. BMC Pharmacology 2008 8:4 doi:10.1186/1471-2210-8-4 |
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